Comprehensive Analysis of lncRNA-Mediated ceRNA Crosstalk and Identification of Prognostic Biomarkers in Wilms' Tumor

BioMed Research International
Hong ZhengFeng-Ting Liu

Abstract

Wilms' tumor (WT) is the most common type of childhood kidney cancer, and most cases present with favorable histology and respond well to standard treatment. However, a subset of patients with WT is diagnosed with bilateral, relapsed, and high-risk tumors which remain the leading cause of cancer-related death in children. Long noncoding RNAs (lncRNAs) and their aberrant expression have currently been attracting great attention as oncogenes or tumor suppressors during tumor initiation and progression. So far, their roles and related competitive endogenous RNA (ceRNA) network remain unelucidated in nephroblastoma pathogenesis. We comprehensively integrated lncRNA, microRNA (miRNA), and messenger RNA (mRNA) expression profiles from the Therapeutically Applicable Research to Generate Effective Treatment (TARGET) database and screened out differentially expressed mRNAs (DEMs), lncRNAs (DELs), and miRNAs (DEMis) to construct a ceRNA network based on the information generated from miRcode, miRTarBase, TargetScan, and miRDB. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed to analyze the functional characteristics of DEMs in the ceRNA network. The interaction between prote...Continue Reading

References

Feb 26, 2009·Cell·Chris P PontingWolf Reik
Aug 2, 2011·Cell·Leonardo SalmenaPier Paolo Pandolfi
Nov 19, 2011·Nature Reviews. Genetics·Manel Esteller
Nov 24, 2011·The Journal of Biological Chemistry·Anthony M BarsottiCarol Prives
Mar 30, 2012·Omics : a Journal of Integrative Biology·Guangchuang YuQing-Yu He
Dec 4, 2012·Nucleic Acids Research·Andrea FranceschiniLars J Jensen
Jul 22, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Fang WangShu-Han Sun
Nov 8, 2014·Nucleic Acids Research·Nathan Wong, Xiaowei Wang
Aug 26, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffrey S DomeKathy Pritchard-Jones
Oct 2, 2015·Database : the Journal of Biological Databases and Curation·Peng WangXia Li
Nov 22, 2015·Nucleic Acids Research·Chih-Hung ChouHsien-Da Huang
Dec 5, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xin YuWilliam Ka Kei Wu
Jun 22, 2017·Biochemical and Biophysical Research Communications·Lin HuangXi Lin
Dec 14, 2017·Cancer Metastasis Reviews·Jongchan KimLi Ma
Aug 16, 2018·EMBO Molecular Medicine·Murugan KalimuthoKum Kum Khanna
Sep 12, 2018·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Yunxiuxiu XuYibiao Ye
Feb 2, 2019·Nature Reviews. Nephrology·Taryn Dora TregerSam Behjati
Feb 9, 2019·Digestive Diseases and Sciences·Jingwei LiuChengzhong Xing
May 20, 2019·Cancer Letters·Zahra AnvarGaetano Verde

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Software Mentioned

MCODE
Cytoscape
TARGET
Search Tool for the
R package
SPSS
clusterProfiler
TargetScan
R
edgeR

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