Comprehensive analysis of long non‑coding RNA using an associated competitive endogenous RNA network in Wilms tumor.

Molecular Medicine Reports
Zhichao WangDayun Sui


Wilms tumor (WT) is the most common malignant renal neoplasm in children; however, the underlying molecular mechanisms are not well understood. According to the competing endogenous RNA (ceRNA) theory, long non‑coding RNAs (lncRNAs) can regulate the expression of target genes by adsorbing microRNAs (miRNAs/miRs). However, the role of lncRNAs in WT has not been fully elucidated. The aim of the present study was to construct a ceRNA network to identify the potential lncRNAs involved in WT. The expression profiles of lncRNAs, miRNAs and mRNAs in 120 WT and six normal tissues were obtained from the Therapeutically Applicable Research to Generate Effective Treatments database. A total of 442 lncRNAs, 214 miRNAs and 4,912 mRNAs were identified as differentially expressed in WT and were enriched in 472 Gene Ontology terms (355 biological processes, 89 cellular components and 29 molecular functions) and 18 Kyoto Encyclopedia of Genes and Genomes pathways. A lncRNA‑miRNA‑mRNA ceRNA network of WT consisting of with 32 lncRNAs, 14 miRNAs and 158 mRNAs was constructed, based on the bioinformatics analysis of the miR target prediction database and the miRNAcode, miRTarBase and TargetScan databases. Subsequently, three lncRNAs, three miRNAs ...Continue Reading


Aug 1, 1990·Molecular and Cellular Biology·G W KrystalJ F Battey
Sep 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D M GreenG J D'Angio
Feb 24, 2001·Journal of the American College of Surgeons·M L RitcheyN E Breslow
Mar 10, 2001·Experimental Cell Research·S B Lee, D A Haber
Apr 3, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D M GreenN E Breslow
May 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel M GreenNorman E Breslow
Oct 22, 2004·Nature·UNKNOWN International Human Genome Sequencing Consortium
Nov 30, 2005·The Oncologist·Monika L Metzger, Jeffrey S Dome
Jan 14, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Cecilia A CottonNorman E Breslow
Feb 26, 2009·Cell·Chris P PontingWolf Reik
Feb 9, 2010·International Journal of Radiation Oncology, Biology, Physics·Irma W E M van DijkLeontien C M Kremer
Mar 9, 2011·Pediatric Blood & Cancer·Amanda M TermuhlenDaniel M Green
Aug 2, 2011·Cell·Leonardo SalmenaPier Paolo Pandolfi
Nov 19, 2011·Nature Reviews. Genetics·Manel Esteller
Mar 30, 2012·Omics : a Journal of Integrative Biology·Guangchuang YuQing-Yu He
Sep 8, 2012·Nature·Sarah DjebaliThomas R Gingeras
Jul 17, 2014·Trends in Molecular Medicine·Josie HayesSean Lawler
Jan 22, 2015·Nucleic Acids Research·Matthew E RitchieGordon K Smyth
Mar 5, 2015·Genes & Development·Peter HohensteinJocelyn Charlton
Apr 5, 2016·International Journal of Molecular Sciences·Nicole LudwigEckart Meese
Apr 14, 2016·Cancer Cell·Adam M Schmitt, Howard Y Chang
Feb 15, 2017·Cancer·Denise Riedel LewisEric J Feuer
Feb 28, 2017·Nature·Chung-Chau HonAlistair R R Forrest
Nov 1, 2017·Genome Biology·Francesco P MarcheseMaite Huarte
Feb 13, 2018·Cellular & Molecular Immunology·Yuli ZhuWei He
Jul 20, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jinlang DongWeiwei Tan
Aug 24, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Shufeng DuanCaixia Chen
Sep 5, 2018·Biochemical and Biophysical Research Communications·Yongzhen LiNa Li
Nov 28, 2018·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Dan FeiYang Zhang

❮ Previous
Next ❯


❮ Previous
Next ❯

Datasets Mentioned


Methods Mentioned


Software Mentioned

clusterProfiler R
R package
GraphPad Prism

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.