Comprehensive analysis of partial epithelial mesenchymal transition-related genes in hepatocellular carcinoma.

Journal of Cellular and Molecular Medicine
Yu LeiPing Han

Abstract

Increasing evidence has revealed that cancer cells undergoing an intermediate state, partial epithelial mesenchymal transition (p-EMT), tend to metastasize rather than complete EMT. We performed a comprehensive analysis of E-cadherin and 25 p-EMT-related genes in HCC to explore the roles and regulatory mechanisms of them in HCC. We analysed E-cadherin and 25 p-EMT-related genes in HCC and constructed an mRNA-miRNA-lncRNA ceRNA subnetwork containing p-EMT-related genes by bioinformatic approaches. IHC was used to identify the protein expression of key p-EMT-related genes, P4HA2, ITGA5, MMP9, MT1X and SPP1. Complete EMT is not necessary for HCC progression. Overexpression of P4HA2, ITGA5, MMP9, SPP1 and down-regulation of MT1X were found in HCC tissues, which were significantly associated with poor prognosis of HCC patients. By means of stepwise reverse prediction and validation from mRNA to lncRNA, an mRNA-miRNA-lncRNA ceRNA subnetwork correlated with HCC prognosis was identified by expression and survival analysis. This study implied that key p-EMT-related genes P4HA2, ITGA5, MMP9, MT1X, SPP1 could be prognostic biomarkers and potential targets of therapy for HCC patients. We constructed an mRNA-miRNA-lncRNA subnetwork containi...Continue Reading

References

Apr 8, 2004·Neoplasia : an International Journal for Oncology Research·Daniel R RhodesArul M Chinnaiyan
May 26, 2004·Biochemical Society Transactions·R L JulianoA Aplin
Aug 2, 2011·Cell·Leonardo SalmenaPier Paolo Pandolfi
Apr 4, 2013·Science Signaling·Jianjiong GaoNikolaus Schultz
Jan 21, 2014·Digestive Diseases and Sciences·Ping HanWei Yan
Sep 25, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Patrick ReichlWolfgang Mikulits
Aug 11, 2015·Frontiers in Oncology·Mohit Kumar JollyHerbert Levine
Oct 7, 2015·Trends in Cell Biology·Xin Ye, Robert A Weinberg
Jul 2, 2016·Cell·M Angela NietoJean Paul Thiery
Oct 22, 2016·Current Opinion in Cell Biology·Maren Diepenbruck, Gerhard Christofori
Dec 8, 2016·Nucleic Acids Research·Damian SzklarczykChristian von Mering
Apr 26, 2017·International Journal of Molecular Medicine·Chengcheng HaoWen G Jiang
Jul 22, 2017·Neoplasia : an International Journal for Oncology Research·Darshan S ChandrashekarSooryanarayana Varambally
Nov 11, 2017·Nucleic Acids Research·Chih-Hung ChouHsien-Da Huang
Jan 9, 2018·Lancet·Alejandro FornerJordi Bruix
May 5, 2018·Journal of Biochemistry·Masao Saitoh
Sep 25, 2018·Journal of Cellular and Molecular Medicine·Junyu LongHaitao Zhao
Sep 30, 2018·Genomics, Proteomics & Bioinformatics·Qiuyu LianJin Gu
Nov 20, 2018·Seminars in Cancer Biology·Pasquale SimeoneDaniele Vergara
Apr 13, 2019·The Journal of Experimental Medicine·Nicole M Aiello, Yibin Kang
Sep 4, 2019·Journal of Cellular Biochemistry·Yun-Zhi YinYan-Hong Tuo
Feb 26, 2020·BMC Bioinformatics·Ying XinTomáš Gedeon
Aug 12, 2020·Translational Oncology·Kritika SaxenaKuppusamy Balamurugan

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Software Mentioned

RNASeq V2 RSEM
ggcorplot
String
VENNY
cBioPortal
Cytoscape
Python
GEPIA
Search Tool
Oncomine

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