Comprehensive analysis of peripheral blood lymphocytes in 76 women with recurrent miscarriage before and after lymphocyte immunotherapy

American Journal of Reproductive Immunology : AJRI
Peiyan LiangYong Zeng

Abstract

The efficacy of lymphocyte immunotherapy (LIT) for unexplained recurrent miscarriage (uRM) remains indefinite. The objective of the present study is to comprehensively evaluate the alterations in the proportions and functions of peripheral blood lymphocytes in patients with uRM before and after LIT. Seventy-six women with uRM were included in the present study. Immunophenotype of peripheral blood lymphocytes (76 patients), NK cytotoxicity (62 patients) and Th1 (IFN-γ and TNF-α)/Th2 (IL-10) ratios (73 patients) were assessed during the luteal phase before LIT and after the third LIT by the flow cytometer. To date, 29 patients had already delivered or been pregnant more than 20 weeks (successful pregnancy group) and 5 patients experienced subsequent abortion (abortion group). The percentages of CD3(+) T cell, CD3(+) CD4(+) T cell and IL-10-producing Th1 cell were significantly increased, whereas the percentages of CD3(+) HLA-DR(+) T cell, CD56(+) CD3(-) NK cell and CD56(dim ) CD16(+) NK cell, the NK cytotoxicity and the ratios of Th1/Th2 were significantly decreased after LIT in the total patients and in the successful pregnant group. The percentages of CD56(+ ) CD3(-) NK cell and IFN-γ-producing cell, and the ratio of IFN-γ/IL-1...Continue Reading

References

Jan 1, 1991·American Journal of Reproductive Immunology : AJRI·H N HoC Y Hsieh
Jan 1, 1995·American Journal of Reproductive Immunology : AJRI·C B CoulamK D Beaman
Mar 1, 1995·American Journal of Reproductive Immunology : AJRI·K HiguchiH Okada
Jul 1, 1994·Human Reproduction·M T IlleniE Radici
Apr 1, 1996·The Journal of Obstetrics and Gynaecology Research·R KishoreS S Agarwal
Jan 1, 1997·American Journal of Reproductive Immunology : AJRI·J H CheckJ Szekeres-Bartho
Nov 14, 1997·Immunology Today·R Raghupathy
May 18, 1999·International Immunology·P MoreauP Paul
Oct 12, 2000·Baillière's Best Practice & Research. Clinical Obstetrics & Gynaecology·L Regan, R Rai
Apr 4, 2001·Human Reproduction Update·S R Choudhury, L A Knapp
Jun 1, 2002·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Dorota Darmochwal-KolarzJan Oleszczuk
Jan 9, 2003·American Journal of Reproductive Immunology : AJRI·Barbara JablonowskaJan Ernerudh
May 8, 2003·American Journal of Reproductive Immunology : AJRI·P von LandenbergY Shoenfeld
Dec 4, 2003·Archives of Gynecology and Obstetrics·Manoj Kumar PandeySuraksha Agrawal
May 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·William R BurnsGeorge Tellides
Nov 14, 2007·American Journal of Reproductive Immunology : AJRI·Taro NonakaKenichi Tanaka
Feb 16, 2008·American Journal of Reproductive Immunology : AJRI·Behrouz Gharesi-FardEskandar Kamali-Sarvestani
Mar 14, 2008·American Journal of Reproductive Immunology : AJRI·David A Clark
Apr 15, 2008·American Journal of Reproductive Immunology : AJRI·Joanne Kwak-Kim, Alice Gilman-Sachs
Mar 25, 2010·American Journal of Reproductive Immunology : AJRI·Nasim KheshtchinAbbas Rezaei
Jan 18, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Vandana SainiJayashree Bhattacharjee

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Citations

Oct 2, 2013·Journal of Human Reproductive Sciences·Ahad ZareMaryam Nourizadeh
Feb 23, 2013·Journal of Reproductive Immunology·Sarah J BlossomCharlotte A Hobbs
Apr 26, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Zehra Sema OzkanEkrem Sapmaz
Dec 23, 2016·Archives of Gynecology and Obstetrics·Marcelo Borges CavalcanteRicardo Barini
Jan 4, 2021·Archives of Gynecology and Obstetrics·Tianli ChangWenpei Xiang
Feb 28, 2021·American Journal of Reproductive Immunology : AJRI·Marcelo Borges CavalcanteRicardo Barini
Jul 19, 2020·International Immunopharmacology·Roghayeh JafarpourMorteza Motallebnezhad

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