Comprehensive analysis of polyamine transport and biosynthesis in the dominant human gut bacteria: Potential presence of novel polyamine metabolism and transport genes

The International Journal of Biochemistry & Cell Biology
Yuta SugiyamaShin Kurihara

Abstract

Recent studies have reported that polyamines in the colonic lumen might affect animal health and these polyamines are thought to be produced by gut bacteria. In the present study, we measured the concentrations of three polyamines (putrescine, spermidine, and spermine) in cells and culture supernatants of 32 dominant human gut bacterial species in their growing and stationary phases. Combining polyamine concentration analysis in culture supernatant and cells with available genomic information showed that novel polyamine biosynthetic proteins and transporters were present in dominant human gut bacteria. Based on these findings, we suggested strategies for optimizing polyamine concentrations in the human colonic lumen via regulation of genes responsible for polyamine biosynthesis and transport in the dominant human gut bacteria.

Citations

May 31, 2018·Bioscience, Biotechnology, and Biochemistry·Yuta SugiyamaShin Kurihara
Jun 23, 2019·Cellular and Molecular Life Sciences : CMLS·Francisca Sánchez-JiménezJosé Luis Urdiales
Oct 28, 2019·International Journal of Molecular Sciences·Panida SittipoYun Kyung Lee
Jan 11, 2018·FEMS Microbiology Letters·Mikiyasu SakanakaShin Kurihara
Mar 30, 2019·Frontiers in Nutrition·Bruno Ramos-MolinaRafael Peñafiel
Sep 12, 2018·Biomolecules·Saif Shahriar Rahman NirzhorSharmind Neelotpol
Jun 2, 2020·Frontiers in Pediatrics·Yaxuan LiLiqing Xu
Oct 16, 2019·Journal of Pharmaceutical and Biomedical Analysis·Jessica FioriRoberto Gotti
Feb 2, 2021·Bioscience of Microbiota, Food and Health·Shin Kurihara
Feb 11, 2021·Medical Sciences : Open Access Journal·Rika HiranoShin Kurihara

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