Comprehensive analysis of protein expression levels and phosphorylation levels in host skin in response to tick (Haemaphysalis longicornis) bite.

Journal of Proteomics
Xiaoli ZhangHui Wang

Abstract

Ticks are parasitic arthropods that suck blood from the surface of most vertebrates. They can transmit a variety of pathogens. The blood sucking of ticks causes varying degrees of damage to the skin of the host. Proteins related to immune regulation, vascular repair, and wound healing in mammalian skin respond to tick bites by regulating their expression and post-translational modifications to protect the skin from injury. Phosphorylation of proteins, as the most common post-translational modification of proteins, plays an important role in the rapid regulation of cell signal transduction, gene expression and cell cycle. To systematically explore the molecular regulatory mechanisms employed by mammalian skin to resist tick bites, larval, nymphal, and adult Haemaphysalis longicornis were used to bite the skin tissues of healthy rabbits in the present study. The quantitative proteomic technology data-independent acquisition was then carried out to investigate in depth the changes in protein expression and phosphorylation in rabbit skin after tick bite. The results showed that among the 4034 proteins and 1795 phosphorylated proteins identified, a total of 202 proteins and 435 phosphorylation sites were changed after H. longicornis...Continue Reading

References

Sep 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·K GalvinM Ozturk
Jan 1, 1987·Annual Review of Entomology·J M Ribeiro
Feb 1, 1985·The Journal of Experimental Medicine·J M RibeiroA Spielman
Jan 1, 1988·The Veterinary Clinics of North America. Small Animal Practice·G C Troy
Apr 1, 1986·The Journal of Cell Biology·J A Rothnagel, G E Rogers
Mar 1, 1981·The Journal of Investigative Dermatology·F GrinnellL Burgess
Jan 1, 1995·Annual Review of Entomology·J R SauerR C Essenberg
Jan 1, 1994·Annual Review of Immunology·R A Seder, W E Paul
Mar 15, 1994·Structure·D A RozwarskiP A Karplus
May 1, 1993·Trends in Biochemical Sciences·M J Hubbard, P Cohen
Jan 1, 1996·Annual Review of Entomology·S K Wikel
Jan 1, 1996·Annual Review of Entomology·J S KlompenJ H Oliver
Jan 1, 1996·Annual Review of Medicine·K K Wu, P Thiagarajan
Aug 26, 1999·Trends in Cell Biology·E L de Hostos
Jul 20, 2001·Annals of the New York Academy of Sciences·M W MosessonD A Meh
Aug 21, 2001·The Journal of Investigative Dermatology·G SzolnokyL Kemény
Sep 5, 2001·Science·P Carmeliet
Dec 1, 2001·The EMBO Journal·A Müller-TaubenbergerG Gerisch
May 11, 2002·Critical Care Medicine·Marcel LeviTom van der Poll
May 30, 2002·Cellular Signalling·László BudayPeter Tamás
Jun 14, 2002·The Biochemical Journal·Otilia V VieiraSergio Grinstein
Feb 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ben J AppelmelkYvette van Kooyk
Dec 1, 1986·Parasitology Today·J O Alexander
Oct 16, 2004·The Journal of Biological Chemistry·Dmitry A SolovjovEdward F Plow
Jun 9, 2005·Parasitology·M Brossard, S K Wikel
Jul 19, 2005·Nature Reviews. Molecular Cell Biology·Barry M Gumbiner
Aug 23, 2005·Thrombosis and Haemostasis·Ivo M B FrancischettiJosé M C Ribeiro
Sep 15, 2005·Biochemical and Biophysical Research Communications·Hideki SumimotoRyu Takeya
Oct 11, 2005·The Journal of Biological Chemistry·Thomas OrfeoKenneth G Mann
Dec 13, 2005·Anais Da Academia Brasileira De Ciências·Bruno B AndradeManoel Barral-Netto
Jan 18, 2006·Nature Cell Biology·Andrés Hurtado-LorenzoVladimir Marshansky
Feb 2, 2006·The Journal of Experimental Biology·Klaus W Beyenbach, Helmut Wieczorek
Jun 30, 2006·Trends in Cell Biology·Andrea C Uetrecht, James E Bear

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Blood Coagulation Signaling Pathways

Coagulation is the process by which a blood clot is formed. This process includes both the formation of a platelet plug as well as a cascade of clotting factors resulting in the formation of fibrin strands. Find the latest research on coagulation signaling pathways here.

Babesiosis

Babesiosis is caused by parasites of the genus babesia, which are transmitted in nature by the bite of an infected tick. Discover the latest research on babesiosis here.