Comprehensive analysis of the expression and prognosis for S100 in human ovarian cancer: A STROBE study

Medicine
Hong-Yu XuQuan Zhou

Abstract

S100 family members are frequently deregulated in human malignancies, including ovarian cancer. However, the prognostic roles of each individual S100 family member in ovarian cancer (OC) patients remain elusive. In the present study, we assessed the prognostic roles and molecular function of 20 individual members of the S100 family in OC patients using GEPIA, Kaplan-Meier plotter, SurvExpress, GeneMANIA and Funrich database. Our results indicated that the mRNA expression levels of S100A1, S100A2, S100A4, S100A5, S100A11, S100A14, and S100A16 were significantly upregulated in patients with OC, and high mRNA expression of S100A1, S100A3, S100A5, S100A6, and S100A13 were significantly correlated with better overall survival, while increased S100A2, S100A7A, S100A10, and S100A11 mRNA expressions were associated with worse prognosis in OC patients. In stratified analysis, the trends of high expression of individual S100 members were nearly the same in different pathological grade, clinical stage, TP53 mutation status, and treatment. More importantly, S100 family signatures may be useful potential prognostic markers for OC. These findings suggest that S100 family plays a vital role in prognostic value and could potentially be an S100...Continue Reading

References

Jan 1, 1995·Brain Research Bulletin·D B ZimmerW Song
Aug 19, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ronald WolfThomas Ruzicka
Jul 20, 2007·Pflügers Archiv : European journal of physiology·Ursula Rescher, Volker Gerke
Jan 2, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Etmar BulkCarsten Müller-Tidow
Aug 4, 2009·Cell Biochemistry and Biophysics·Honglin HeYan Yu
Dec 4, 2009·Pathology Oncology Research : POR·Fengjin QinLi Geng
Jun 4, 2010·Amino Acids·Susann WolfJens Pietzsch
Jun 22, 2011·Applied Immunohistochemistry & Molecular Morphology : AIMM·Li J WangMurray B Resnick
Nov 21, 2013·Experimental and Therapeutic Medicine·Bin LiuHai-Cheng Gao
Dec 10, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ying-Fu LiuChun-Hua Luo
Feb 1, 2014·International Journal of Molecular Medicine·Yi-Fei JiMing-Bing Xiao
Jan 17, 2015·Journal of Translational Medicine·Manish KumarRanju Ralhan
Jan 24, 2015·Nature Reviews. Cancer·Anne R BresnickDanna B Zimmer
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Jun 23, 2015·Oncoscience·Juna LeeChulso Moon
Aug 2, 2015·Gynecologic Oncology·Dag Andre NymoenBen Davidson
Nov 21, 2015·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·György SölétormosRaphael Molina
Jan 20, 2016·International Journal of Oncology·Taiki MasudaKenichi Sugihara
Feb 20, 2016·Oncology Letters·Jingfeng QianZhumei Cui
Mar 2, 2016·Translational Research : the Journal of Laboratory and Clinical Medicine·Noor A LokmanCarmela Ricciardelli
Mar 24, 2016·Journal of Translational Medicine·Jing ZhongRen-xian Cao
Jan 5, 2017·Scientific Reports·Shizhen ZhangXiaochen Wang
Feb 17, 2017·British Journal of Cancer·Shana J KimJoanne Kotsopoulos
Apr 19, 2017·Cellular and Molecular Life Sciences : CMLS·Rosario DonatoIleana Giambanco
Jun 8, 2017·Experimental and Therapeutic Medicine·Ran TaoHai-Jun Li
Aug 2, 2017·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Michael J DuffyJohn Crown
Nov 18, 2017·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ting WangTing Wang
Dec 5, 2017·BMC Biophysics·Lucas C Wheeler, Michael J Harms
Feb 17, 2018·JAMA : the Journal of the American Medical Association·Jill Jin
Feb 17, 2018·JAMA : the Journal of the American Medical Association·UNKNOWN US Preventive Services Task ForceChien-Wen Tseng
Jun 19, 2018·Nucleic Acids Research·Max FranzQuaid Morris
Jan 9, 2019·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Apr 30, 2019·Cancer Biomarkers : Section a of Disease Markers·Nan MaYingzhuan Zhan

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Datasets Mentioned

BETA
GSE9891
GSE32062

Methods Mentioned

BETA
glycosylation

Software Mentioned

SurvExpress
FunRich
GEPIA
GeneMANIA

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