Comprehensive analysis of the expression patterns of the adenylate cyclase gene family in the developing and adult mouse brain

The Journal of Comparative Neurology
Axel ViselGregor Eichele

Abstract

Adenylate cyclases (Adcys) are components of several developmentally, neurophysiologically, and pharmacologically relevant signaling pathways. A prominent feature of Adcys is their ability to integrate multiple signaling pathways into a single second messenger pathway, the production of cAMP. Nine isoforms of membrane-bound Adcys are known, each encoded by a distinct gene. These isoforms differ in their response to regulatory upstream pathways as well as in their distribution in the brain and elsewhere. Use of various detection methods and animal species has, however, hampered a direct comparison of expression patterns, so the potential contribution of single isoforms to Adcy activity in different brain regions remains unclear. We have determined the expression patterns of all nine Adcy genes in the embryonic, postnatal day 7, and adult mouse brain by nonradioactive robotic in situ hybridization (ISH). Here we describe the salient features of these patterns. Regional colocalization of Adcy transcripts encoding isoforms with different regulatory properties was detected in the cortex, subregions of the hippocampus, olfactory bulb, thalamus, and striatum. Hence, our expression data support models for modulation of cAMP signaling b...Continue Reading

References

Jan 1, 1992·Canadian Journal of Physiology and Pharmacology·R A Swanson
Aug 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M Yoshimura, D M Cooper
Oct 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·R T PremontR Iyengar
Sep 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·S KatsushikaY Ishikawa
Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·P G FeinsteinR R Reed
Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·B N Gao, A G Gilman
Jan 1, 1990·Annual Review of Biochemistry·S S TaylorW Yonemoto
Sep 25, 1995·Biochemical and Biophysical Research Communications·J M PatersonF A Antoni
Sep 15, 1995·The Journal of Biological Chemistry·G A WaymanD R Storm
May 12, 1995·The Journal of Biological Chemistry·K HellevuoB Tabakoff
Jan 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·Z L WuD R Storm
Jun 1, 1997·Trends in Biochemical Sciences·M D Houslay, G Milligan
Jul 14, 1998·Nature Genetics·R M Abdel-MajidP E Neumann
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·M J SmitR Iyengar
Dec 18, 1998·Science·H KawasakiA M Graybiel
Jan 6, 1999·Proceedings of the National Academy of Sciences of the United States of America·J BuckL R Levin
Apr 27, 2000·Cellular Signalling·Y Chern
Mar 27, 2001·Annual Review of Pharmacology and Toxicology·J Hanoune, N Defer
Oct 9, 2002·Current Opinion in Neurobiology·James P CarsonGregor Eichele
Dec 6, 2002·Nature·Alexandre ReymondAndrea Ballabio
Nov 19, 2003·The Journal of Comparative Neurology·Wilma C G Van StaverenJan De Vente
Dec 19, 2003·Nucleic Acids Research·Axel ViselGregor Eichele

❮ Previous
Next ❯

Citations

Oct 7, 2009·Psychopharmacology·Michael J McCarthyMaria Hadjiconstantinou
Mar 19, 2013·Cellular and Molecular Neurobiology·Jason M Conley, Val J Watts
Apr 26, 2012·Journal of Molecular Neuroscience : MN·Petra EhlingThomas Budde
Apr 2, 2009·Nature Reviews. Drug Discovery·Sandra PierreKlaus Scholich
Apr 15, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zhenshan WangDaniel R Storm
Feb 5, 2009·Neurochemical Research·Gonzalo SánchezEdgar Kornisiuk
Jul 11, 2006·The Journal of Physiology·Gonzalo Alvarez-Bolado, Gregor Eichele
Apr 1, 2011·Trends in Pharmacological Sciences·Rajarshi SenguptaJoshua B Rubin
Dec 22, 2015·Journal of Chemical Neuroanatomy·Yuanfeng Zhang, Gonzalo Alvarez-Bolado
Mar 19, 2014·The European Journal of Neuroscience·Xavier Nicol, Patricia Gaspar
Jan 22, 2008·The International Journal of Neuropsychopharmacology·Liad MannGalila Agam
Apr 1, 2004·Gene Expression Patterns : GEP·Judit OldekampThomas Skutella
Nov 5, 2016·Developmental Neurobiology·Henrik Gezelius, Guillermina López-Bendito
Jan 26, 2016·Nature Reviews. Neuroscience·Serena M DudekShannon Farris
Jul 7, 2007·Physiological Reviews·Debbie Willoughby, Dermot M F Cooper
Jul 24, 2020·PLoS Computational Biology·Hidetoshi UrakuboShin Ishii
Jan 5, 2019·Naunyn-Schmiedeberg's Archives of Pharmacology·James SimpsonFerenc A Antoni
Jul 26, 2016·Experimental and Therapeutic Medicine·Xinghua ZhangJie Zhang
Jul 3, 2020·Frontiers in Synaptic Neuroscience·Douglas A Caruana, Serena M Dudek
Oct 23, 2020·Expert Review of Neurotherapeutics·Cécile DelormeEmmanuel Roze
Feb 12, 2020·Neuroscience and Biobehavioral Reviews·Elentina K ArgyrousiJos Prickaerts
Mar 18, 2021·Translational Research : the Journal of Laboratory and Clinical Medicine·Joseph B O'Brien, David L Roman
Jul 3, 2021·International Journal of Molecular Sciences·Nicholas H HarbinJohn R Hepler
Oct 20, 2007·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Honglei LiCunshuan Xu
Oct 27, 2021·Physiological Reviews·Katrina F OstromRennolds S Ostrom

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.