Comprehensive analysis of the skin fungal microbiota of astronauts during a half-year stay at the International Space Station

Medical Mycology
Takashi SugitaChiaki Mukai

Abstract

The International Space Station (ISS) is a huge manned construct located approximately 400 km above the earth and is inhabited by astronauts performing space experiments. Because the station is within a closed microgravity environment, the astronauts are subject to consistent stress. This study analyzed the temporal changes in the skin fungal microbiota of 10 astronauts using pyrosequencing and quantitative PCR assay before, during, and after their stay in the ISS. Lipophilic skin fungi, Malassezia predominated most samples regardless of the collection period, body site (cheek or chest), or subject. During their stay in the ISS, the level of Malassezia colonization changed by 7.6- ± 7.5-fold (mean ± standard deviation) and 9.5- ± 24.2-fold in cheek and chest samples, respectively. At the species level, M. restricta, M. globosa, and M. sympodialis were more abundant. In the chest samples, the ratio of M. restricta to all Malassezia species increased, whereas it did not change considerably in cheek samples. Fungal diversity was reduced, and the ratio of Malassezia to all fungal colonization increased during the astronauts' stay at the ISS. The ascomycetous yeast Cyberlindnera jadinii was detected in abundance in the in-flight sam...Continue Reading

References

Aug 1, 1995·Internal Medicine·M AndoM Miyajima
Oct 1, 1995·Clinical Microbiology Reviews·K C Hazen
Dec 18, 2003·Journal of the European Academy of Dermatology and Venereology : JEADV·A K Gupta, R Bluhm
Dec 31, 2005·The Journal of Investigative Dermatology. Symposium Proceedings·Yvonne M DeAngelisThomas L Dawson
Jul 22, 2006·Microbiology and Immunology·Takashi SugitaAkemi Nishikawa
Sep 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·J W WilsonC A Nickerson
Feb 16, 2008·The British Journal of Dermatology·A L CogenR L Gallo
Jun 19, 2008·Genomics, Proteomics & Bioinformatics·Sara D AltenburgLinda E Hyman
Mar 20, 2010·Environmental Microbiology·Aurélie CrabbéPierre Cornelis
Aug 13, 2010·Journal of Clinical Microbiology·Zhan GaoMartin J Blaser
Jan 29, 2011·The Lancet Infectious Diseases·Marisa H MiceliSamuel A Lee
Oct 31, 2012·International Journal of Cosmetic Science·A Gordon JamesJennifer E Pople
May 24, 2013·Nature·Keisha FindleyJulia A Segre
Nov 26, 2013·Seminars in Immunology·James A Sanford, Richard L Gallo
Dec 11, 2013·Beneficial Microbes·G J M Christensen, H Brüggemann
Apr 4, 2014·Applied Microbiology and Biotechnology·Kasthuri VenkateswaranJay Perry
May 7, 2014·Free Radical Research·X W MaoD S Gridley
Jun 3, 2014·Brain, Behavior, and Immunity·S K MehtaD L Pierson
Sep 17, 2015·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Otomi ChoTakashi Sugita

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Citations

Mar 15, 2018·Medical Mycology·Bart TheelenThomas L Dawson
Mar 14, 2019·The New England Journal of Medicine·Jan StepanekScott Parazynski
Apr 12, 2019·Astrobiology·Gilke De MiddeleerSarah De Saeger
Aug 8, 2019·Proceedings. Biological Sciences·Jane M LucasEmily K Meineke
Jul 19, 2017·Microbiome·Nicholas A BeKasthuri Venkateswaran
Nov 20, 2019·International Journal of Cosmetic Science·R SfrisoR Campiche
Feb 6, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·C VlachosD M Saunte
Jul 22, 2020·Journal of Applied Microbiology·R SiddiquiN A Khan
Jul 21, 2020·BioMed Research International·Yanwu ChenQiong Xie
Aug 28, 2020·Frontiers in Microbiology·Ting ZhuZhe-Xue Quan
Apr 5, 2019·MSystems·Xinzhao TongPatrick K H Lee
Jul 12, 2017·Microbiome·A BlachowiczK Venkateswaran
Jun 30, 2019·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Mako KawaiMasao Nasu
Jan 5, 2021·Microbiology and Immunology·Kazuo SatohKoichi Makimura
May 18, 2021·IScience·Swati BijlaniClay C C Wang
Aug 17, 2021·Frontiers in Microbiology·David DankoKasthuri Venkateswaran
Jun 1, 2021·Skin Appendage Disorders·Supriya PunyaniJames Schwartz
Sep 24, 2021··Natalia A. Koltovaya, Veronika S. Elizarova

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