Comprehensive approach to diabetic nephropathy

Kidney Research and Clinical Practice
Bancha Satirapoj, Sharon G Adler

Abstract

Diabetic nephropathy (DN) is a leading cause of mortality and morbidity in patients with diabetes. This complication reflects a complex pathophysiology, whereby various genetic and environmental factors determine susceptibility and progression to end-stage renal disease. DN should be considered in patients with type 1 diabetes for at least 10 years who have microalbuminuria and diabetic retinopathy, as well as in patients with type 1 or type 2 diabetes with macroalbuminuria in whom other causes for proteinuria are absent. DN may also present as a falling estimated glomerular filtration rate with albuminuria as a minor presenting feature, especially in patients taking renin-angiotensin-aldosterone system inhibitors (RAASi). The pathological characteristic features of disease are three major lesions: diffuse mesangial expansion, diffuse thickened glomerular basement membrane, and hyalinosis of arterioles. Functionally, however, the pathophysiology is reflected in dysfunction of the mesangium, the glomerular capillary wall, the tubulointerstitium, and the vasculature. For all diabetic patients, a comprehensive approach to management including glycemic and hypertensive control with RAASi combined with lipid control, dietary salt re...Continue Reading

Citations

Mar 19, 2019·Clinical Genetics·Kyung H JeongUNKNOWN Representing KNOW-CKD Study Group and KNDP Study Group
Sep 28, 2016·Journal of Diabetes Research·Bancha SatirapojOuppatham Supasyndh
May 28, 2019·Journal of Cellular Biochemistry·Maggie M RamzyRabeh K Saleh
May 5, 2020·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Sangmi LeeSeung Hyeok Han
Aug 28, 2020·Journal of Diabetes Research·Kachonsak YongwatanaBancha Satirapoj
Jan 24, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Emad YuzbashianFereidoun Azizi
Nov 11, 2017·Scientific Reports·Magdalena KrochmalAntonia Vlahou
Mar 27, 2018·Journal of Diabetes Research·Bancha Satirapoj
Oct 27, 2015·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Dingting WuXuehong Dong
Apr 18, 2015·PloS One·Bancha SatirapojOuppatham Supasyndh
Nov 2, 2019·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Hadis MozaffariShahab Alizadeh
Aug 31, 2021·Frontiers in Endocrinology·Anqi ChenYanan Li
Apr 11, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ali F Abdel-WahabSaeed S Al Ghamdi
Jan 26, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yan CuiYun Liu

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Methods Mentioned

BETA
glycosylation
biopsy
electron microscopy
pharmacotherapy

Software Mentioned

ONTARGET

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