Comprehensive assessment of vascular health in patients; towards endothelium-guided therapy

Pharmacological Reports : PR
Marzena FrolowStefan Chlopicki

Abstract

Endothelial function has diagnostic, prognostic and therapeutic significance. A number of non-invasive techniques were introduced for its assessment, including flow-mediated dilation (FMD), finger plethysmography (RH-PAT) and digital thermal monitoring (DTM). All these methods can be performed simultaneously. In addition, various methods for measuring arterial wall stiffness are available such as: pulse wave analysis (PWA), pulse wave velocity (PWV), pulse contour analysis (PCA) and carotid wall distensibility coefficient (DC). Finally, carotid intima-media thickness (cIMT) and ankle brachial index (ABI) are used as surrogate read-outs of atherosclerosis. Here, we briefly describe the advantages, limitations and interrelationships of various methods used for the assessment of endothelial function, arterial stiffness, and present the concept of an integrated evaluation of vascular health based on multiple methods. This strategy may be useful to stratify cardiovascular risk and represents a step towards multiparametric assessment of endothelium for effective endothelium-guided therapy in patients with cardiovascular diseases.

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Citations

Sep 1, 2015·Pharmacological Reports : PR·Stefan Chlopicki
May 18, 2016·British Journal of Pharmacology·Andreas DaiberThomas Münzel
Jul 1, 2016·Expert Review of Cardiovascular Therapy·Hanna A Jensen, Jawahar L Mehta
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Jun 28, 2018·Pediatric Cardiology·Omar QayumGeetha Raghuveer
Oct 25, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Yusuf ÜstünNecati Örmeci
Dec 6, 2017·Journal of Clinical Biochemistry and Nutrition·Yutaka OdanakaHiroshi Tamai
May 8, 2018·BMC Cardiovascular Disorders·Daoyuan SiPing Yang
Apr 1, 2019·Cancer Reports·Bhanu Prasad VenkatesuluSunil Krishnan
Aug 20, 2019·Vascular Pharmacology·Anna BarStefan Chlopicki
Mar 9, 2021·Molecular Metabolism·Alexander TaceyItamar Levinger

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