Comprehensive bactericidal activity of an ethanol-based hand gel in 15 seconds.

Annals of Clinical Microbiology and Antimicrobials
Günter Kampf, Angela Hollingsworth

Abstract

Some studies indicate that the commonly recommended 30 s application time for the post contamination treatment of hands may not be necessary as the same effect may be achieved with some formulations in a shorter application time such as 15 s. We evaluated the bactericidal activity of an ethanol-based hand gel (Sterillium Comfort Gel) within 15 s in a time-kill-test against 11 Gram-positive, 16 Gram-negative bacteria and 11 emerging bacterial pathogens. Each strain was evaluated in quadruplicate. The hand gel (85% ethanol, w/w) was found to reduce all 11 Gram-positive and all 16 Gram-negative bacteria by more than 5 log10 steps within 15 s, not only against the ATCC test strains but also against corresponding clinical isolates. In addition, a log10 reduction > 5 was observed against all tested emerging bacterial pathogens. The ethanol-based hand gel was found to have a broad spectrum of bactericidal activity in only 15 s which includes the most common species causing nosocomial infections and the relevant emerging pathogens. Future research will hopefully help to find out if a shorter application time for the post contamination treatment of hands provides more benefits or more risks.

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Citations

Oct 31, 2008·BMC Infectious Diseases·Günter KampfPaul-Michael Kaulfers
Mar 14, 2009·The Journal of Hospital Infection·E Lingaas, M Fagernes
Jul 30, 2011·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Catherine Firanek, Steven Guest
Jun 23, 2020·MicrobiologyOpen·Andreas Sauerbrei
Jun 18, 2019·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·D PiresD Pittet
Aug 3, 2020·International Journal of Pharmaceutics·Kenji KikuchiTakuji Ishikawa
Feb 19, 2020·The Journal of Hospital Infection·J B X TanD Pittet

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