Comprehensive characterization of temperature- and pressure-induced bilayer phase transitions for saturated phosphatidylcholines containing longer chain homologs

Colloids and Surfaces. B, Biointerfaces
Masaki GotoH Matsuki

Abstract

Complete elucidation of the phase behavior of phospholipid bilayers requires information on the subtransition from the lamellar crystal (Lc) phase to the gel phase. However, for bilayers of saturated diacylphosphatidylcholines (CnPCs), especially longer chain homologs, equilibration in the Lc phase is known to be very slow. In this study, bilayer phase transitions of three CnPCs with longer acyl chains, C19PC, C20PC and C21PC, were observed by differential scanning calorimetry under atmospheric pressure and by light-transmittance measurements under high pressure. Using lipid samples treated by thermal annealing enabled the observation of the sub-, pre- and main transitions of the C19PC and C20PC bilayers under atmospheric pressure. Only the pre- and main transitions could be observed for the C21PC bilayer due to very slow kinetics of the Lc phase formation for lipids with long acyl chains. The temperature and pressure phase diagrams constructed and phase-transitions quantities (enthalpy, entropy and volume changes) evaluated for these bilayers were compared with one another and with those of bilayers of the CnPC homologs examined in previous studies. These results allowed us (1) to clarify the temperature- and pressure-dependen...Continue Reading

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Jan 11, 2011·Colloids and Surfaces. B, Biointerfaces·Masaki GotoHitoshi Matsuki
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Apr 28, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Masaki GotoShoji Kaneshina
Jul 4, 2012·Biochimica Et Biophysica Acta·Md Arif Kamal, V A Raghunathan
Jul 25, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Masaki GotoHitoshi Matsuki
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Oct 15, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Ashkan RahmaniMichael R Morrow

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Citations

Sep 21, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Collin KnightMichael R Morrow
Apr 4, 2017·Biochimica Et Biophysica Acta. Biomembranes·Hitoshi MatsukiShoji Kaneshina
Apr 2, 2019·Chemical & Pharmaceutical Bulletin·Hitoshi MatsukiNobutake Tamai
Mar 17, 2017·Bioscience, Biotechnology, and Biochemistry·Kazutaka Yamamoto
Jul 24, 2021·Chemistry and Physics of Lipids·Masaki GotoHitoshi Matsuki
Sep 29, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Valeria NeleMolly M Stevens

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