Comprehensive chromosome screening and embryo selection: moving toward single euploid blastocyst transfer

Seminars in Reproductive Medicine
E J FormanR T Scott

Abstract

Interest in using aneuploidy screening to select embryos has been renewed with the introduction of new methods for comprehensive chromosome screening (CCS) that evaluate all 24 chromosomes. With a series of experiments providing level I evidence of accuracy, reliability, safety, predictive value, and clinical efficacy, CCS-based selection of a single euploid blastocyst may provide an opportunity to finally realize the potential benefits and practical application of elective single embryo transfer. Furthermore, by incorporating CCS into research and development to control for chromosomal contribution to reproductive potential, additional biomarkers may now be more readily identified that help to further enhance the efficacy of embryo selection technology. This review describes the critical components of a valid CCS embryo selection methodology and discusses the limitations and opportunities for future routine application in reproductive medicine.

Citations

Jun 22, 2013·Current Opinion in Obstetrics & Gynecology·Yvonne E M Koot, Nick S Macklon
Apr 30, 2014·BioMed Research International·Ermanno GrecoFrancesco Fiorentino
Aug 13, 2014·Trends in Molecular Medicine·Jason M Franasiak, Richard T Scott
Feb 11, 2016·Journal of Assisted Reproduction and Genetics·Norbert GleicherDavid H Barad
May 30, 2013·Fertility and Sterility·UNKNOWN Practice Committees of the American Society for Reproductive Medicine and the Society for Assisted Reproductive Technology
Jan 9, 2015·Human Reproduction Update·David K GardnerNathan R Treff
Dec 3, 2013·Journal of Molecular Histology·Deng LixinXie Hongbin
Apr 5, 2016·Current Opinion in Obstetrics & Gynecology·Caroline JuneauNathan Treff
May 26, 2018·Zygote : the Biology of Gametes and Early Embryos·Lluc CollAnna Veiga
Jan 23, 2021·Reproductive Sciences·Fabiana B KohlrauschDavid L Keefe
Aug 7, 2021·Systems Biology in Reproductive Medicine·Papri SarkarAnthony N Imudia

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.