Comprehensive Clinical, Diagnostic, and Advanced Imaging Characterization of the Ocular Surface in Spontaneous Aqueous Deficient Dry Eye Disease in Dogs

Cornea
Brian C LeonardSara M Thomasy

Abstract

To perform a comprehensive clinical, diagnostic, and imaging characterization of the ocular surface in West Highland White Terriers (WHWTs) diagnosed with aqueous deficient dry eye (ADDE) disease. Six ADDE-affected and 13 ADDE-unaffected WHWT dogs were enrolled and underwent clinical assessment and disease scoring, tear osmolarity, phenol red thread test, Schirmer tear test, tear film breakup time, fluorescein staining, Rose bengal and lissamine green vital dye staining, meibometry, corneal esthesiometry, ultrasound pachymetry, optical coherence tomography, in vivo confocal microscopy, and conjunctival biopsy. Subjective assessment of their condition was provided by owner-reported surveys. ADDE-affected WHWT dogs had higher median clinical disease (conjunctiva: 5.75 vs. 0.00; cornea: 14.00 vs. 5.00; total: 17.50 vs. 5.00), vital staining (Rose bengal: 2.25 vs. 1.50; lissamine green: 2.00 vs. 1.00), and histologic disease (conjunctiva: 2 vs. 0) scores when compared with the controls. In addition, ADDE-affected WHWTs had significantly lower phenol red thread test (5.0 vs. 17.5, mm/15 s), Schirmer tear test (3 vs. 20, mm/min), tear film breakup time (3.6 vs. 13.9, s) values and higher area under the curve values for meibometry (39...Continue Reading

References

Apr 1, 1979·Clinical Immunology and Immunopathology·F W QuimbyR M Lewis
May 1, 1990·The Veterinary Clinics of North America. Small Animal Practice·R L Kaswan, M A Salisbury
Mar 12, 1988·The Veterinary Record·D J Sutton, N J Roach
Aug 25, 2001·Experimental Eye Research·P Argüeso, I K Gipson
Feb 17, 2007·Journal of the American Veterinary Medical Association·Gia KlaussDebra A Crawford
Mar 27, 2007·The Journal of Small Animal Practice·R F SanchezF M Billson
Apr 12, 2007·The Journal of Small Animal Practice·D L WilliamsM F Heath
May 9, 2009·Survey of Ophthalmology·Eric Donnenfeld, Stephen C Pflugfelder
Jan 16, 2013·American Journal of Ophthalmology·Reina FukudaShiro Amano
Jul 6, 2014·Investigative Ophthalmology & Visual Science·Pietro Emanuele NapoliMaurizio Fossarello
Jan 31, 2015·Journal of the American Veterinary Medical Association·Lionel SebbagDavid J Maggs
Oct 9, 2015·Science Translational Medicine·Amir KolDori L Borjesson
Nov 21, 2015·Clinical Ophthalmology·Richard PotvinChristopher J Rapuano
Jan 10, 2016·Investigative Ophthalmology & Visual Science·Bernardo Yáñez-SotoChristopher J Murphy
Jan 23, 2016·Veterinary Ophthalmology·Lionel SebbagDavid J Maggs
Jul 28, 2016·Investigative Ophthalmology & Visual Science·Sara M ThomasyChristopher J Murphy
Sep 11, 2016·Experimental Eye Research·Brian C LeonardChristopher J Murphy
Jul 25, 2017·The Ocular Surface·J Daniel NelsonDavid A Sullivan
Jul 25, 2017·The Ocular Surface·Jennifer P CraigFiona Stapleton
Jul 25, 2017·The Ocular Surface·Mark D P WillcoxLyndon Jones
Jul 25, 2017·The Ocular Surface·James S WolffsohnJennifer P Craig
Oct 7, 2017·The British Journal of Ophthalmology·Tommy C Y ChanVishal Jhanji
Oct 23, 2017·Ophthalmology·Stephen C Pflugfelder, Cintia S de Paiva
Dec 15, 2017·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Joshua Seth EatonChristopher J Murphy

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Citations

Sep 23, 2020·Veterinary Ophthalmology·Akihiko SaitoReiko Arita
Jan 11, 2020·Frontiers in Veterinary Science·Lionel SebbagJonathan P Mochel
Oct 13, 2020·Experimental Eye Research·Sneh PatelAnat Galor
Sep 19, 2020·Cornea·Brian C LeonardSara M Thomasy

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