Comprehensive dissection of the medial temporal lobe in AD: measurement of hippocampus, amygdala, entorhinal, perirhinal and parahippocampal cortices using MRI

Journal of Neurology
Stefan J TeipelHarald Hampel

Abstract

Early pathological involvement of specific medial temporal lobe areas is characteristic for Alzheimer's disease (AD). To determine the extent of regional medial temporal lobe atrophy, including hippocampus, amygdala, and entorhinal, perirhinal, and parahippocampal cortices in mild AD patients and healthy controls, and to compare diagnostic accuracy across volumetric markers. We studied 34 patients with clinically probable AD and 22 healthy elderly control subjects. Regional volumetric measures were obtained from volumetric T1-weighted MRI scans after accounting for global brain atrophy using affine transformation into standard space. Volumes of medial temporal lobe structures were significantly smaller in AD patients than in controls with exception of the left entorhinal cortex. The degree of atrophy was comparable between all structures. Diagnostic accuracy (number of correctly allocated cases divided by number of all cases) was highest for the right parahippocampal cortex with 85%, but only slightly lower for the right hippocampus and right entorhinal cortex with 82% and 84%. Using a linear combination of markers, the unilateral volumes of the right hippocampus, parahippocampal cortex and perirhinal cortex yielded an accuracy...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Oct 1, 1980·Archives of Neurology·A G Herzog, T L Kemper
Mar 1, 1994·Journal of Computer Assisted Tomography·D L CollinsA C Evans
Mar 24, 1997·The Journal of Comparative Neurology·G SimićN Bogdanović
Jan 1, 1997·International Psychogeriatrics·M J de LeonL A Saint Louis
Apr 30, 1998·Neurobiology of Aging·K JuottonenH Soininen
Jun 9, 1998·IEEE Transactions on Medical Imaging·J G SledA C Evans
Jan 29, 1999·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·C D SmithL C Pettigrew
Feb 19, 1999·Lancet·M BobinskiH M Wisniewski
Jun 12, 1999·Dementia and Geriatric Cognitive Disorders·M GolebiowskiA Pfeffer
Sep 18, 2001·Archives of Neurology·J L PriceJ C Morris
Sep 19, 2001·Journal of Neurology, Neurosurgery, and Psychiatry·A T DuM W Weiner
Nov 14, 2001·Neurobiology of Aging·B C DickersonL deToledo-Morrell
Jan 26, 2002·Journal of the Neurological Sciences·Harald HampelHans-Jürgen Möller
Apr 24, 2002·Neurology·R J KillianyM S Albert
Feb 22, 2003·NeuroImage·Gaël Chetelat, Jean-Claude Baron
May 5, 2004·Neurobiology of Aging·Corina PennanenHilkka Soininen

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Citations

Jul 14, 2010·Archives of Neurology·Matthew A WarnerRamon Diaz-Arrastia
Jul 6, 2007·Der Nervenarzt·H HampelK Bürger
Jan 22, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Stefan J TeipelHarald Hampel
May 20, 2008·Neuroscience·R ThangavelA Zaheer
May 5, 2010·International Journal of Computer Assisted Radiology and Surgery·Klaus H FritzscheHans-Peter Meinzer
Feb 2, 2016·Ageing Research Reviews·Lorenzo PiniGiovanni B Frisoni
Feb 2, 2016·Neurobiology of Aging·Sabine KrummKirsten I Taylor
May 7, 2013·The Medical Clinics of North America·Stefan J TeipelHarald Hampel
Sep 11, 2012·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Qian ShenRanjan Duara
Sep 6, 2012·Psychiatry Research·Thomas van BruggenKlaus H Fritzsche
Jan 9, 2016·Molecular Neurobiology·Xi-Chen ZhuUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Apr 7, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Claudio BabiloniPaolo M Rossini
Aug 1, 2009·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Claudio BabiloniPaolo M Rossini
Jul 15, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Evelin L SchaefferAlvaro G Mendes-Neto
Jul 18, 2008·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Harald HampelKaj Blennow
Aug 18, 2009·Neuropathology and Applied Neurobiology·G SimicP R Hof
Apr 8, 2010·Journal of Magnetic Resonance Imaging : JMRI·Ying WuRobert R Edelman
Apr 9, 2008·IEEE Transactions on Medical Imaging·S DuchesneD L Collins
Jun 8, 2007·IEEE Transactions on Bio-medical Engineering·Dong SongTheodore W Berger
Feb 11, 2015·Neurobiology of Aging·Eva LouwersheimerUNKNOWN Alzheimer's Disease Neuroimaging Initiative and Dementia Competence Network
Apr 1, 2014·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·R Scott MackinPatricia A Arean
May 25, 2010·Psychiatry Research·Stefan J TeipelHarald Hampel
Aug 11, 2016·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Stefan TeipelUNKNOWN FTLDc study group
Nov 3, 2016·Frontiers in Aging Neuroscience·Xiangyu MaUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Sep 24, 2016·Journal of Alzheimer's Disease : JAD·Babak A ArdekaniUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
May 3, 2007·Journal of Integrative Neuroscience·Evian GordonLeanne M Williams
Mar 17, 2018·Journal of Clinical and Experimental Neuropsychology·Jocelyne C WhiteheadJennifer D Ryan
Feb 25, 2018·Journal of Prosthodontic Research·Takuya KobayashiHisatomo Kondo
Sep 27, 2018·Brain Imaging and Behavior·Warren D TaylorBennett A Landman
Nov 7, 2008·Expert Review of Neurotherapeutics·Geraldo F BusattoMarcus V Zanetti

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