Comprehensive Evaluation of the Oral Health Status, Salivary Gland Function, and Oxidative Stress in the Saliva of Patients with Subacute Phase of Stroke: A Case-Control Study

Journal of Clinical Medicine
Piotr GerrethKatarzyna Hojan

Abstract

This is the first study to assess, comprehensively, the oral health status; salivary glands' function and enzymatic and non-enzymatic antioxidant defense; and oxidative damage to proteins and lipids in the non-stimulated (NWS) and stimulated (SWS) whole saliva of stroke patients. The study included 30 patients in the subacute phase of the stroke and an age and gender-matched control group. We showed that the activity of antioxidant enzymes (catalase and salivary peroxidase) was significantly higher in both NWS and SWS of stroke patients, similarly to uric acid concentration. However, in the study group, the reduced glutathione (GSH) concentration in SWS decreased. The contents of protein glycooxidation products (advanced glycation end products (AGE) and protein oxidation products (AOPP)) and lipid hydroperoxides were significantly higher in NWS and SWS of stroke patients. In the study group there was also a decrease in stimulated saliva secretion and total protein content. Interestingly, products of protein and lipid oxidation correlate negatively with SWS flow. The ROC analysis showed that salivary GSH with 100% specificity and 100% sensitivity differentiates the analyzed groups (AUC = 1.0). To sum up, in subacute stroke patie...Continue Reading

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Citations

Oct 3, 2020·Journal of Clinical Medicine·Gerhard Schmalz, Dirk Ziebolz
Jan 26, 2021·Oxidative Medicine and Cellular Longevity·Mateusz MaciejczykKarolina Gerreth
Jan 29, 2021·Oxidative Medicine and Cellular Longevity·Nikola M StojanovićNiko S Radulović
Mar 30, 2021·Oxidative Medicine and Cellular Longevity·Jinnan DuanJifang Sheng
Apr 27, 2021·Oxidative Medicine and Cellular Longevity·Mateusz MaciejczykKarolina Gerreth
Jul 10, 2021·Oxidative Medicine and Cellular Longevity·Barbara ChoromańskaMateusz Maciejczyk
Aug 27, 2021·Scientific Reports·Mateusz MaciejczykKarolina Gerreth

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Methods Mentioned

BETA
glycation

Software Mentioned

GraphPad Prism
R
ClinCalc
GraphPad

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