Comprehensive Evolutionary Analysis of the Major RNA-Induced Silencing Complex Members

Scientific Reports
Rui ZhangDonghai Li

Abstract

RNA-induced silencing complex (RISC) plays a critical role in small interfering RNA (siRNA) and microRNAs (miRNA) pathways. Accumulating evidence has demonstrated that the major RISC members (AGO, DICER, TRBP, PACT and GW182) represent expression discrepancies or multiple orthologues/paralogues in different species. To elucidate their evolutionary characteristics, an integrated evolutionary analysis was performed. Here, animal and plant AGOs were divided into three classes (multifunctional AGOs, siRNA-associated AGOs and piRNA-associated AGOs for animal AGOs and multifunctional AGOs, siRNA-associated AGOs and complementary functioning AGOs for plant AGOs). Animal and plant DICERs were grouped into one class (multifunctional DICERs) and two classes (multifunctional DICERs and siRNA-associated DICERs), respectively. Protista/fungi AGOs or DICERs were specifically associated with the siRNA pathway. Additionally, TRBP/PACT/GW182 were identified only in animals, and all of them functioned in the miRNA pathway. Mammalian AGOs, animal DICERs and chordate TRBP/PACT were found to be monophyletic. A large number of gene duplications were identified in AGO and DICER groups. Taken together, we provide a comprehensive evolutionary analysis,...Continue Reading

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Citations

Dec 2, 2020·International Journal of Molecular Sciences·Jordy M M Kocken, Paula A da Costa Martins
Nov 28, 2020·Oncotarget·Adewale Oluwaseun FadakaMervin Meyer
Dec 17, 2021·PLoS Pathogens·Tomoko TakahashiNicholas F Parrish

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Methods Mentioned

BETA
X-ray

Software Mentioned

DICERs
MUSCLE ( MUltiple Sequence Comparison
MEGA7
SMART ( Simple Modular Architecture Research Tool
BLAST
MUSCLE
Loquacious
SMART
Chordata

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