Comprehensive Examination of Therapies for Pain in Parkinson's Disease: A Systematic Review and Meta-Analysis

Neuroepidemiology
Abdul Rehman QureshiRuqqiyah Rana

Abstract

Pain in Parkinson's disease (PD) is a debilitating symptom with a prevalence of 68%, yet is untreated 50% of the time. What is unclear, however, is which treatment is optimal for minimizing pain severity in PD. Thus, the objective of this systematic review and meta-analysis was to investigate the efficacy of a variety of novel, complimentary, and conventional treatments for pain in PD and elucidate which therapy is the most effective. A systematic search was performed using MEDLINE, PsycINFO, Embase, CINAHL, and CENTRAL databases. To identify additional articles, manual searches of reference lists of included trials were also searched. Major neurology conference proceedings occurring between January 2014 and February 2018 were also searched to identify unpublished studies that may be potentially eligible. Twenty-five randomized controlled trials that encompassed medical, surgical, and complementary therapies met our inclusion criteria and exhibited moderate quality evidence. Two reviewers conducted assessments for study eligibility, risk of bias, data extraction, and quality of evidence rating. A conservative random-effects model was used to pool effect estimates of pain severity. The greatest reductions in pain were found with...Continue Reading

Citations

Jan 9, 2019·The International Journal of Neuroscience·Abdul Qayyum RanaRuqqiyah Rana
Jul 11, 2019·Expert Opinion on Pharmacotherapy·Wolfgang H Jost, Carsten Buhmann
Jun 24, 2020·Journal of Neural Transmission·Christian GeroinMichele Tinazzi
Jun 23, 2020·Journal of Parkinson's Disease·Carsten BuhmannWolfgang H Jost
Apr 14, 2021·Lancet·Bastiaan R BloemChristine Klein
May 16, 2021·Journal of Neurology·J NaisbyA J Yarnall
Jun 19, 2021·Drug Design, Development and Therapy·Giovanni AbbruzzeseFabrizio Stocchi
Jul 20, 2021·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Javier PagonabarragaWolfgang H Jost
Nov 28, 2019·Clinical Parkinsonism & Related Disorders·Yi-Cheng Tai, Chin-Hsien Lin
Jul 9, 2021·Journal of Geriatric Psychiatry and Neurology·Jenni NaisbyKatherine Baker
Aug 28, 2021·Journal of Personalized Medicine·Diego Santos GarcíaCristina Martínez Miró
Nov 30, 2021·Phytotherapy Research : PTR·Rachel RieraAna Luiza Cabrera Martimbianco
Jan 29, 2022·Der Nervenarzt·V MyliusJ C Möller

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