Comprehensive gene expression analysis in human periodontal ligaments of the mandibular third molars performing vertical movement and the maxillary second premolars with occlusal contact

Orthodontics & Craniofacial Research
N Suda

Abstract

The periodontal ligament (PDL) is thought to be an important tissue in vertical movement during tooth eruption, but the precise molecular mechanism is not known. Thereto, comprehensive gene expression was analyzed in human PDL of mandibular third molars performing vertical movement and maxillary second premolars with occlusal contact. The expression profile of 9,243 genes in the PDL of one subject was compared between vertically moving third molars and second premolars with occlusal contact by DNA microarray. The expression of 27 genes showed more than a 10-fold difference between third molars and second premolars. The expression of CALB1 (encoding calbindin 1), CYP26A1 (encoding cytochrome P450, family 26, subfamily A, polypeptide 1), SPOCK3 (encoding testican-3), CCK (encoding cholecystokinin) and SCRG1 (encoding scrapie responsive protein 1) was more than 30-fold higher in PDLs of the third molars than the second premolars. CALB1 is reported to increase at the pressure side of PDL during experimental orthodontic tooth movement in rats. Interestingly, in this study, CALB1 expression showed the largest difference. In contrast, CRCT1 (encoding cysteine-rich C-terminal 1), SPRP3 (encoding small proline-rich protein 3), IL8 (enco...Continue Reading

References

Feb 1, 1992·Experimental Cell Research·M S EllerB A Gilchrest
Sep 1, 1995·Journal of Dental Research·G E WiseL Zhao
Sep 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·W M PhilbrickA C Karaplis
Jun 1, 2000·Proceedings of the National Academy of Sciences of the United States of America·I A NakchbandiA E Broadus
Jan 29, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Hiroyuki KanzakiHideo Mitani
Mar 28, 2002·Nucleic Acids Research·Ramesh RamakrishnanAbhijit Mazumder
Apr 16, 2002·Nature Genetics·Thomas Perlmann
Aug 23, 2002·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·G E WiseR N D'Souza
Jan 17, 2003·Molecular and Cellular Biology·George Steele-PerkinsRichard M Gronostajski
Apr 27, 2004·Journal of Bone and Mineral Metabolism·Tomotaka SuzukiKimie Ohyama
May 6, 1966·Science·R H Wasserman, A N Taylor

❮ Previous
Next ❯

Citations

Nov 2, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Ali Nabavizadeh
Jul 21, 2012·European Journal of Oral Sciences·Michal JágrIvan Mikšík

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.