Comprehensive genome analyses of Sellimonas intestinalis, a potential biomarker of homeostasis gut recovery.

Microbial Genomics
Marina MuñozDaniel Paredes-Sabja

Abstract

Sellimonas intestinalis is a Gram-positive and anaerobic bacterial species previously considered as uncultivable. Although little is known about this Lachnospiraceae family member, its increased abundance has been reported in patients who have recovered from intestinal homeostasis after dysbiosis events. In this context, the aim of the present study was to take advantage of a massive in vitro culture protocol that allowed the recovery of extremely oxygen-sensitive species from faecal samples, which led to isolation of S. intestinalis. Whole genome analyses of 11 S. intestinalis genomes revealed that this species has a highly conserved genome with 99.7 % 16S rRNA gene sequence similarity, average nucleotide polymorphism results >95, and 50.1 % of its coding potential being part of the core genome. Despite this, the variable portion of its genome was informative enough to reveal the existence of three lineages (lineage-I including isolates from Chile and France, lineage-II from South Korea and Finland, and lineage-III from China and one isolate from the USA) and evidence of some recombination signals. The identification of a cluster of orthologous groups revealed a high number of genes involved in metabolism, including amino acid...Continue Reading

References

Dec 11, 1999·Nucleic Acids Research·D L WheelerB A Rapp
Jan 6, 2004·Nucleic Acids Research·Dean Laslett, Bjorn Canback
Oct 14, 2005·Molecular Biology and Evolution·Daniel H Huson, David Bryant
Mar 30, 2006·Antimicrobial Agents and Chemotherapy·Jun IshikawaHiroyuki Satoh
Apr 25, 2007·Nucleic Acids Research·Karin LagesenDavid W Ussery
Nov 30, 2007·Nucleic Acids Research·UNKNOWN UniProt Consortium
Apr 16, 2008·Nucleic Acids Research·Jason R Grant, Paul Stothard
Apr 21, 2009·Molecular Biology and Evolution·Morgan N PriceAdam P Arkin
Oct 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Michael Richter, Ramon Rosselló-Móra
Mar 10, 2010·BMC Bioinformatics·Doug HyattLoren J Hauser
Dec 2, 2010·Microbiology and Molecular Biology Reviews : MMBR·Vanderlene L KungAlan R Hauser
Apr 14, 2011·The Veterinary Clinics of North America. Small Animal Practice·Jan S Suchodolski
Oct 1, 2011·Genome Medicine·Stephanie Om Dyke, Tim Jp Hubbard
Nov 29, 2011·Current Topics in Microbiology and Immunology·Michael Blaut
Nov 29, 2011·Nucleic Acids Research·Kim D PruittDonna R Maglott
Nov 29, 2011·Molecular Ecology·Aleeza C Gerstein, Moore Jean-Sébastien
Mar 28, 2012·Nature Reviews. Gastroenterology & Hepatology·Marianne H FraherEamonn M M Quigley
Jul 12, 2012·The Journal of Antimicrobial Chemotherapy·Ea ZankariMette Voldby Larsen
Aug 1, 2012·Nature Methods·Diego DarribaDavid Posada
Oct 13, 2012·Bioinformatics·Limin FuWeizhong Li
Nov 30, 2012·Nucleic Acids Research·Christian QuastFrank Oliver Glöckner
Jan 19, 2013·Molecular Biology and Evolution·Kazutaka Katoh, Daron M Standley
Jun 20, 2013·Nature Immunology·Jonathan R Brestoff, David Artis
Jul 19, 2013·Genome Research·Catherine A LozuponeRob Knight
Sep 7, 2013·Bioinformatics·Eric P Nawrocki, Sean R Eddy
Oct 23, 2013·Antimicrobial Agents and Chemotherapy·Sushim Kumar GuptaJean-Marc Rolain
Nov 15, 2013·Nucleic Acids Research·Alice R WattamBruno W Sobral
Feb 14, 2014·Biology Letters·Taichi A Suzuki, Michael Worobey
Mar 20, 2014·Bioinformatics·Torsten Seemann
Apr 12, 2014·PLoS Computational Biology·Remco BouckaertAlexei J Drummond
Apr 30, 2014·Antimicrobial Agents and Chemotherapy·Alessandra CarattoliHenrik Hasman
Apr 29, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Willem van Schaik
Jul 23, 2015·Bioinformatics·Andrew J PageJulian Parkhill
Sep 16, 2015·Genes·Michael R GillingsSasha G Tetu
Nov 19, 2015·Nucleic Acids Research·Lihong ChenQi Jin
Dec 8, 2015·International Journal of Systematic and Evolutionary Microbiology·Boram SeoGwangPyo Ko
Mar 30, 2016·Drug Design, Development and Therapy·Marco Krasselt, Christoph Baerwald
Oct 30, 2016·Nucleic Acids Research·Baofeng JiaAndrew G McArthur
Dec 16, 2016·The New England Journal of Medicine·Susan V Lynch, Oluf Pedersen
Jun 9, 2017·PLoS Computational Biology·Ryan R WickKathryn E Holt
Nov 16, 2017·Nucleic Acids Research·Nicole SilvesterGuy Cochrane

❮ Previous
Next ❯

Citations

Aug 17, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Riao Dao Eerdunchaolu

❮ Previous
Next ❯

Software Mentioned

_ Filter _
ANNOT
Tracer
Prodigal
Tree Annotator
Beast
Infernal
Protein
CGview
CD

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.