Comprehensive imaging of gastroesophageal biopsy samples by spectrally encoded confocal microscopy.

Gastrointestinal Endoscopy
DongKyun KangGuillermo J Tearney

Abstract

Spectrally encoded confocal microscopy (SECM) is a high-speed reflectance confocal microscopy technique that has the potential to be used for acquiring comprehensive images of the entire distal esophagus endoscopically with subcellular resolution. The goal of this study was to demonstrate large-area SECM in upper GI tissues and to determine whether the images contain microstructural information that is useful for pathologic diagnosis. A feasibility study. Gastrointestinal Unit, Massachusetts General Hospital. Fifty biopsy samples from 36 patients undergoing routine EGD were imaged by SECM, in their entirety, immediately after their removal. The microstructure seen in the SECM images was similar to that seen by histopathology. Gastric cardia mucosa was clearly differentiated from squamous mucosa. Gastric fundic/body type mucosa showed more tightly packed glands than gastric cardia mucosa. Fundic gland polyps showed cystically dilated glands lined with cuboidal epithelium. The presence of intraepithelial eosinophils was detected with the cells demonstrating a characteristic bilobed nucleus. Specialized intestinal metaplasia was identified by columnar epithelium and the presence of goblet cells. Barrett's esophagus (BE) with dyspl...Continue Reading

References

Jun 16, 2001·The Journal of Investigative Dermatology·M HuzairaS González
May 10, 2002·Journal of Gastroenterology and Hepatology·Ralph S DacostaNorman E Marcon
Oct 26, 2005·Gastrointestinal Endoscopy·Adrian L PolglasePeter M Delaney
Nov 5, 2005·Journal of Microscopy·H-X Wu, L Ji
Dec 13, 2005·Best Practice & Research. Clinical Gastroenterology·Louis-Michel Wong Kee Song, Brian C Wilson
Jun 3, 2006·Microscopy Research and Technique·Martin CapekLucie Kubínová
Jun 8, 2006·Microscopy Research and Technique·Vanessa Campo-RuizSalvador González
Jul 18, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Ralf KiesslichMarkus F Neurath
Mar 27, 2007·Gastrointestinal Endoscopy·Benjamin J VakocBrett E Bouma
Apr 6, 2007·Optics Letters·D YelinG J Tearney
Jun 27, 2007·Gastrointestinal Endoscopy·Shigeto YoshidaKazuaki Chayama
Sep 5, 2007·Gastrointestinal Endoscopy·Valentin BeckerAlexander Meining
Dec 19, 2007·Optics Letters·G J TearneyB E Bouma
Sep 3, 2008·Journal of Gastroenterology and Hepatology·Nam Q Nguyen, Rupert W L Leong
Sep 16, 2008·Best Practice & Research. Clinical Gastroenterology·Ralf KiesslichMarkus F Neurath
Oct 18, 2008·Gastrointestinal Endoscopy·Timothy J MuldoonRebecca Richards-Kortum
Oct 18, 2008·Gastrointestinal Endoscopy·Melissa J SuterGuillermo J Tearney
Oct 3, 2005·Optics Express·C BoudouxG Tearney

❮ Previous
Next ❯

Citations

Feb 8, 2013·Journal of Biomedical Optics·Sanjee AbeytungeMilind Rajadhyaksha
Aug 15, 2012·Diagnostic Pathology·Charles S Carignan, Yukako Yagi
Oct 2, 2013·Journal of Voice : Official Journal of the Voice Foundation·Mary J HawkshawRobert T Sataloff
Jun 19, 2013·Journal of Voice : Official Journal of the Voice Foundation·Mary J HawkshawRobert T Sataloff
Jun 6, 2013·Gastrointestinal Endoscopy Clinics of North America·Kerry B Dunbar
Jan 19, 2016·Laboratory Investigation; a Journal of Technical Methods and Pathology·Elena F BrachtelDongkyun Kang
Nov 26, 2010·Gastroenterology Clinics of North America·Marcia Irene Canto
Feb 23, 2012·Journal of Biomedical Optics·Meagan A SalduaKristen C Maitland
Sep 17, 2016·Lasers in Surgery and Medicine·Dongkyun KangGuillermo J Tearney
Aug 15, 2014·Optics Letters·Adel Zeidan, Dvir Yelin
Oct 25, 2013·Biomedical Optics Express·Dongkyun KangGuillermo J Tearney
Aug 10, 2012·Biomedical Optics Express·Guy EngelDvir Yelin
Jul 31, 2019·Biomedical Optics Express·Cheng GongDongkyun Kang
Jun 24, 2011·Biomedical Optics Express·Dongkyun KangGuillermo J Tearney
Jan 28, 2014·Biomedical Optics Express·Nima TabatabaeiGuillermo J Tearney
Jun 29, 2012·Biomedical Optics Express·Sri-Rajasekhar KothapalliSanjiv Sam Gambhir
Jan 8, 2019·Lasers in Surgery and Medicine·Dongkyun KangGuillermo J Tearney
Oct 2, 2019·Bioengineering & Translational Medicine·Si ChenLinbo Liu
Nov 26, 2015·Biomedical Optics Express·Adel Zeidan, Dvir Yelin
May 21, 2011·Current Opinion in Gastroenterology·Kerry B Dunbar
Sep 21, 2013·Biomedical Optics Express·Simon C SchlachterGuillermo J Tearney
Nov 6, 2020·Biomedical Optics Express·Seunghun LeeKi Hean Kim
Dec 2, 2020·Lasers in Surgery and Medicine·Christopher D NguyenDongkyun Kang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Barrett Esophagus

Barrett’s esophagus if a serious complication of gastroesophageal reflux disease during which the normal esophageal lining changes to tissue that resembles intestinal lining. Here is the latest research.