Comprehensive immune characterization and T-cell receptor repertoire heterogeneity of retroperitoneal liposarcoma

Cancer Science
Liang YanChunyi Hao

Abstract

Retroperitoneal liposarcoma (RLPS) is one of the most common subtypes of retroperitoneal soft tissue sarcomas and lacks effective treatment. This study aimed to provide a thorough profile of immune characteristics of RLPS. This study included 56 RLPS patients. Multisite tumor tissues were collected from 16 patients. Immunohistochemistry was carried out to identify CD4+ , CD8+ , FoxP3+ , CD20+ , or programmed cell death-1 (PD-1)+ tumor infiltrating lymphocytes (TILs) and  Programmed cell death ligand-1 (PD-L1) expression in tumor tissues. Ultradeep sequencing of T-cell receptor (TCR) β-chain gene was carried out in 42 tumor samples as well as peripheral blood samples collected from 6 patients. In RLPS, TILs were distributed in 3 patterns and T cells were more prevalent than B cells. Generally, the proportion of TILs decreased and PD-L1 expression increased with tumor progression. Patients with higher PD-1/PD-L1 expression tended to have poorer prognosis, whereas patients with tertiary lymphoid structure tended to have a favorable disease-free survival. Although T-cell clones in tumors were quite different from those in peripheral blood, TCR sequencing showed low TCR repertoire reads as well as polyclonal status within tumors, wh...Continue Reading

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Citations

Feb 3, 2021·Journal for Immunotherapy of Cancer·Harsimrat Kaur BirdiMichele Ardolino
Jan 28, 2021·International Journal of Molecular Sciences·Emi MashimaMotonobu Nakamura
Nov 2, 2020·Cancer Treatment Reviews·Mayanne M T ZhuTorsten O Nielsen
Aug 8, 2021·Cancers·Luana Madalena SousaPaulo Rodrigues-Santos
Sep 2, 2021·Journal for Immunotherapy of Cancer·Brett A SchroederSeth M Pollack
Dec 7, 2021·Frontiers in Oncology·Lixuan CuiChunyi Hao

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Datasets Mentioned

BETA
PRJNA516984

Methods Mentioned

BETA
surgical resection
PCR

Software Mentioned

MEGA
Aperio ImageScope
BLAST

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