Comprehensive investigation of marine Actinobacteria associated with the sponge Halichondria panicea

Applied and Environmental Microbiology
Imke SchneemannJohannes F Imhoff

Abstract

Representatives of Actinobacteria were isolated from the marine sponge Halichondria panicea collected from the Baltic Sea (Germany). For the first time, a comprehensive investigation was performed with regard to phylogenetic strain identification, secondary metabolite profiling, bioactivity determination, and genetic exploration of biosynthetic genes, especially concerning the relationships of the abundance of biosynthesis gene fragments to the number and diversity of produced secondary metabolites. All strains were phylogenetically identified by 16S rRNA gene sequence analyses and were found to belong to the genera Actinoalloteichus, Micrococcus, Micromonospora, Nocardiopsis, and Streptomyces. Secondary metabolite profiles of 46 actinobacterial strains were evaluated, 122 different substances were identified, and 88 so far unidentified compounds were detected. The extracts from most of the cultures showed biological activities. In addition, the presence of biosynthesis genes encoding polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) in 30 strains was established. It was shown that strains in which either PKS or NRPS genes were identified produced a significantly higher number of metabolites and exhibited...Continue Reading

References

Mar 1, 1977·Antimicrobial Agents and Chemotherapy·L DolakO K Sebek
May 1, 1977·Antimicrobial Agents and Chemotherapy·C Reading, M Cole
Jul 1, 1991·The Journal of Antibiotics·Y NishimotoY Yamada
Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Aug 1, 1989·The Journal of Antibiotics·S TohmaH Seto
Dec 1, 1986·The Journal of Antibiotics·U FauthH Achenbach
Dec 1, 1985·The Journal of Antibiotics·Y IkedaH Umezawa
Jun 1, 1971·The Journal of Antibiotics·K MaedaT Takeuchi
Sep 1, 1973·The Journal of Antibiotics·T AoyagiH Morishima
May 15, 1974·Journal of the American Chemical Society·K F KochE Wenkert
Jun 1, 1969·Tetrahedron Letters·M UramotoH Yonehara
Dec 1, 1983·The Journal of Antibiotics·K IshimaruS Nakamura
Feb 1, 1982·The Journal of Antibiotics·S OmuraH Tanaka
Jun 1, 1982·The Journal of Antibiotics·H NakanoF Tomita
Nov 1, 1981·The Journal of Antibiotics·D J Warnick-PickleR J White
Sep 1, 1995·The Journal of Antibiotics·N FukuchiA Suzuki
Oct 1, 1993·Research in Microbiology·J J SanglierT Fehr
Jan 1, 1993·The Journal of Antibiotics·M ToriyaK Matsumoto
Feb 1, 1993·The Journal of Antibiotics·N ImamuraH Sano
Jun 1, 1997·The Journal of Antibiotics·K PuseckerH Weyland
Aug 1, 1997·The Journal of Antibiotics·A KuwaharaY Uehara
Nov 14, 1997·The Journal of Antibiotics·C J BarrowR Cooper
Mar 25, 1998·The Journal of Antibiotics·P R GraupnerC E Snipes
May 8, 1998·Bioscience, Biotechnology, and Biochemistry·H KanzakiK Kawazu
Aug 26, 1998·The Journal of Antibiotics·T MorishitaT Okazaki
May 29, 1999·The Journal of Antibiotics·K Hayashi, H Nozaki
Jul 21, 1999·Journal of Biotechnology·Murray H G MunroA R Duckworth
Nov 5, 1999·FEMS Microbiology Letters·M Metsä-KeteläK Ylihonko
Nov 30, 1999·Chemical & Pharmaceutical Bulletin·N HosokawaM Hori
Sep 23, 2000·Journal of Natural Products·Carsten PuderA Zeeck
Nov 23, 2000·Journal of Natural Products·V J MukkuE Helmke
Feb 13, 2001·Metabolic Engineering·S Doekel, M A Marahiel
Jan 5, 2002·Bioorganic & Medicinal Chemistry Letters·Jane B LaursenJohn Nielsen
Feb 6, 2002·The Journal of Antibiotics·K TakahashiKazuhiko Kurosawa
Mar 25, 2004·Natural Product Reports·John W BluntMichèle R Prinsep
Jul 30, 2004·Natural Product Reports·Jorn Piel
Aug 31, 2004·Journal of Natural Products·Romila D CharanGuy T Carter
Oct 23, 2004·Journal of Natural Products·Ben ClarkJennifer H Gill
Nov 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jörn PielShigeki Matsunaga
Feb 24, 2005·Antonie van Leeuwenhoek·Hans-Peter FiedlerGerhard Mihm
Feb 24, 2005·Antonie van Leeuwenhoek·Paul R JensenWilliam Fenical
Apr 14, 2005·Progress in Molecular and Subcellular Biology·Johannes F Imhoff, R Stöhr
Apr 20, 2005·The Journal of Antibiotics·Masatoshi AbeTetsushi Saino
Sep 15, 2005·The Journal of Antibiotics·Kosaku TakahashiKazuhiko Kurosawa
Oct 28, 2005·The Journal of Biological Chemistry·Haren ArulananthamChristopher J Schofield
Jan 20, 2006·FEMS Microbiology Ecology·Ute HentschelMichael W Taylor
Mar 18, 2006·FEMS Microbiology Ecology·A WichelsG Gerdts
May 6, 2006·Current Opinion in Microbiology·Kin S Lam
Oct 25, 2006·FEMS Microbiology Ecology·Vera ThielJohannes F Imhoff
May 17, 2007·Environmental Microbiology·Nicole S Webster
Jun 8, 2007·Microbiology and Molecular Biology Reviews : MMBR·Michael W TaylorMichael Wagner
Jun 15, 2007·Antonie van Leeuwenhoek·Shumei JiangXiang Li
Nov 13, 2007·Trends in Microbiology·Alan T Bull, James E M Stach
Apr 10, 2008·Journal of Natural Products·Maya I MitovaJohannes F Imhoff
Mar 24, 2009·Applied and Environmental Microbiology·Cristiane C P HardoimJan Dirk van Elsas

Citations

Sep 24, 2013·Applied Microbiology and Biotechnology·Ramesh Subramani, William Aalbersberg
Jan 12, 2011·Marine Biotechnology·Paula TabaresUte Hentschel
Jan 31, 2013·Antonie van Leeuwenhoek·Klementyna Karlińska-Batres, Gert Wörheide
Jan 29, 2013·Molekuliarnaia biologiia·O V KaliuzhnaiaB V Itskovich
Jul 4, 2012·International Journal of Molecular Sciences·Lijun XiYing Huang
Jul 24, 2012·Marine Drugs·Sheila Marie Pimentel-ElardoUte Hentschel
Jun 16, 2011·Marine Drugs·Imke SchneemannJohannes F Imhoff
May 16, 2014·Marine Drugs·Usama Ramadan AbdelmohsenUte Hentschel
Jul 30, 2014·Applied Microbiology and Biotechnology·Karuppiah ValliappanZhiyong Li
Dec 4, 2015·International Journal of Molecular Sciences·Rafael R C CuadratAlberto M R Dávila
Mar 23, 2011·Biotechnology Advances·Johannes F ImhoffJutta Wiese
Oct 19, 2010·Current Opinion in Biotechnology·Kelley A GallagherPaul R Jensen
May 7, 2015·Microbiological Research·Tahsin BennurVaishali Javdekar
May 5, 2016·Marine Drugs·Anak Agung Gede IndraningratDetmer Sipkema
Jun 15, 2016·Journal of Natural Products·Haibo ZhangChangsheng Zhang
Jun 28, 2016·Journal of Industrial Microbiology & Biotechnology·P OndrejíčkováM Čertík
Oct 30, 2018·Drug Development Research·Jutta Wiese, Johannes F Imhoff
May 20, 2019·Journal of Cellular Biochemistry·Ajitha Gomathi, Kodiveri Muthukalianan Gothandam
Feb 6, 2014·Natural Product Reports·Usama Ramadan AbdelmohsenUte Hentschel
Feb 1, 2015·Veterinary World·Milagro García BernalJosé Manuel Mazón-Suástegui
Nov 6, 2015·Frontiers in Microbiology·Weiqi KuangLijuan Long
Feb 2, 2017·Frontiers in Microbiology·Scott W BehieMatthew F Traxler
Feb 28, 2019·International Microbiology : the Official Journal of the Spanish Society for Microbiology·Ignacio SottorffJohannes F Imhoff
Jul 20, 2019·Scientific Reports·Stephen KnoblochViggó Marteinsson
Jan 21, 2021·Microorganisms·Yitayal S AntenehChristopher M M Franco

Related Concepts

Non-ribosomal peptide synthase
Bacterial Proteins
DNA, Bacterial
DNA, Ribosomal
Peptide synthase
Phylogeny
Demospongiae
RNA, Ribosomal, 16S
Seawater
Disease Clustering

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Archaeal RNA Polymerase

Archaeal RNA polymerases are most similar to eukaryotic RNA polymerase II but require the support of only two archaeal general transcription factors, TBP (TATA-box binding protein) and TFB (archaeal homologue of the eukaryotic general transcription factor TFIIB) to initiate basal transcription. Here is the latest research on archaeal RNA polymerases.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.