Comprehensive molecular characterization of pediatric treatment-induced high-grade glioma: A distinct entity despite disparate etiologies with defining molecular characteristics and potential therapeutic targets

doi:10.1101/809772

Comprehensive molecular characterization of pediatric treatment-induced high-grade glioma: A distinct entity despite disparate etiologies with defining molecular characteristics and potential therapeutic targets

bioRxiv

Oct 25, 2019

John A DeSistoAdam L. Green

DOI: 10.1101/809772

Get paper from

Abstract

Treatment-induced high-grade gliomas (TIHGGs) are an incurable late complication of cranial radiation therapy or combined radiation/chemotherapy used to treat pediatric cancer. We assembled a cohort of 33 TIHGGs from multiple institutions. The primary antecedent malignancies were medull...read more

Mentioned in this Paper

Astrocytoma

Malignant Neoplasms

Chromosomes

Complication

DNA

DNA Repair

Ependymoma

Glioma

Helper-Inducer T-Lymphocyte

Medulloblastoma

Paper Details

References

References
Citations

References currently unavailable
We're still populating references for this paper, please check back later.

References
Citations

No citations available
This paper may not have been cited yet.

Sonic Hedgehog Signaling

The Sonic Hedgehog signaling pathway regulates developmental processes including cell patterning and differentiation and plays a role in tissue repair and regeneration. Here is the latest research on this complex signal transduction pathway.

Telomere Dysfunction

Telomere dysfunction in response to critical telomere shortening induces dna damage checkpoints that lead to cell cycle arrest and/or cell death.

Precision Oncology

Precision oncology is a new approach to cancer treatment, which utilizes the molecular profiling of each tumor to develop and tailor treatment strategies to each patient. The use of these biomarkers from tumors will help to predict those who will respond to specific treatments. Here is the latest research on precision oncology.

Pediatric Brain Tumor Consortium (PBTC)

The Pediatric Brain Tumor Consortium (PTBC) mission is to is to contribute rapidly and effectively to the understanding and cure of pediatric brain tumors through the conduct of multi-center, multidisciplinary, innovative studies with designs and analyses based on uniformly high-quality statistical science. To stay updated on the research from this institute, please follow this feed.

Comparative Sequencing

Inter/Intra-Species: Comparative Sequencing describes the sequencing techniques that compare between and within species genomes. Discover the latest research on comparative sequencing of inter/intra-species here.

Medulloblastoma

Medulloblastoma is a malignant brain tumor that starts in the cerebellum and spreads through the cerebrospinal fluid to other parts of the CNS. Here is the latest research on this cancer.

BioRxiv Preprints

BioRxiv is the preprint server for biology, operated by Cold Spring Harbor Laboratory. Here are the latest biology preprint articles from bioRxiv.

DNA Repair

DNA repair is critical to prevent detrimental mutations and maintain genomic stability that can otherwise lead to disease and disability. There are a number of different mechanisms of repair including base excision repair, direct repair, nucleotide excision repair and double-strand break repair. Discover the latest research on DNA repair here.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.

Spinal Cord Neoplasms

Spinal cord neoplasms affect the spinal cord and arise from either within the spinal cord or from extramedullary structures that surround the spinal cord. The cancer can arise from different cell types such as the meninges surrounding the spinal cord, glial or nerve cells within the CNS. Here is the latest research on spinal cord neoplasms.

Follicular T Helper Cells

Follicular t helper cells are an important subset of helper t-cells which help to the formation of germinal centers and b-cells differentiation. Discover the latest research on follicular t helper cells here.

Human Tumor Atlas (Preprints)

The Human Tumor Atlas is a collaborative project that uses detailed maps of a variety of cancers to investigate cancer development, metastasis, and treatments. Discover the latest preprints from the Human Tumor Atlas here.