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Comprehensive molecular characterization of pediatric treatment-induced high-grade glioma: A distinct entity despite disparate etiologies with defining molecular characteristics and potential therapeutic targets

bioRxiv

Oct 25, 2019

John A DeSistoAdam L. Green

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Abstract

Treatment-induced high-grade gliomas (TIHGGs) are an incurable late complication of cranial radiation therapy or combined radiation/chemotherapy used to treat pediatric cancer. We assembled a cohort of 33 TIHGGs from multiple institutions. The primary antecedent malignancies were medull...read more

Mentioned in this Paper

Astrocytoma
Malignant Neoplasms
Chromosomes
Complication
DNA
DNA Repair
Ependymoma
Glioma
Helper-Inducer T-Lymphocyte
Medulloblastoma
11
1
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Comprehensive molecular characterization of pediatric treatment-induced high-grade glioma: A distinct entity despite disparate etiologies with defining molecular characteristics and potential therapeutic targets

bioRxiv

Oct 25, 2019

John A DeSistoAdam L. Green

DOI: 10.1101/809772

Abstract

Treatment-induced high-grade gliomas (TIHGGs) are an incurable late complication of cranial radiation therapy or combined radiation/chemotherapy used to treat pediatric cancer. We assembled a cohort of 33 TIHGGs from multiple institutions. The primary antecedent malignancies were medull...read more

Mentioned in this Paper

Astrocytoma
Malignant Neoplasms
Chromosomes
Complication
DNA
11
1

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