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Comprehensive mutational scanning of a kinase in vivo reveals substrate-dependent fitness landscapes

bioRxiv

Apr 18, 2014

Alexandre MelnikovTarjei S Mikkelsen

Abstract

Deep mutational scanning has emerged as a promising tool for mapping sequence-activity relationships in proteins, RNA and DNA. In this approach, diverse variants of a sequence of interest are first ranked according to their activities in a relevant pooled assay, and this ranking is then...read more

Mentioned in this Paper

Amino Acids, Essential
Assay
In Vivo
Antibiotics
Antibiotics, Aminoglycoside
Antibiotics, Antitubercular
Phosphotransferases
Protein Engineering
Entamoeba coli
RNA
12
4
Paper Details
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Comprehensive mutational scanning of a kinase in vivo reveals substrate-dependent fitness landscapes

bioRxiv

Apr 18, 2014

Alexandre MelnikovTarjei S Mikkelsen

PMID: 990004317

DOI: 10.1101/004317

Abstract

Deep mutational scanning has emerged as a promising tool for mapping sequence-activity relationships in proteins, RNA and DNA. In this approach, diverse variants of a sequence of interest are first ranked according to their activities in a relevant pooled assay, and this ranking is then...read more

Mentioned in this Paper

Amino Acids, Essential
Assay
In Vivo
Antibiotics
Antibiotics, Aminoglycoside
Antibiotics, Antitubercular
Phosphotransferases
Protein Engineering
Entamoeba coli
RNA
12
4
Paper Details
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  • Citations
  • finger pointing at paper

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