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Comprehensive mutational scanning of a kinase in vivo reveals substrate-dependent fitness landscapes

bioRxiv

Apr 18, 2014

Alexandre MelnikovTarjei S. Mikkelsen

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Abstract

Deep mutational scanning has emerged as a promising tool for mapping sequence-activity relationships in proteins, RNA and DNA. In this approach, diverse variants of a sequence of interest are first ranked according to their activities in a relevant pooled assay, and this ranking is then...read more

Mentioned in this Paper

Amino Acids, Essential
Antibiotics
Antibiotics, Aminoglycoside
Antibiotics, Antitubercular
DNA
Escherichia coli
Phosphotransferases
Protein Engineering
RNA
Entamoeba coli
12
4
Paper Details
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  • Comprehensive mutational scanning of a kinase in vivo reveals substrate-dependent fitness landscapes

    bioRxiv

    Apr 18, 2014

    Alexandre MelnikovTarjei S. Mikkelsen

    PMID: 990004317

    DOI: 10.1101/004317

    Abstract

    Deep mutational scanning has emerged as a promising tool for mapping sequence-activity relationships in proteins, RNA and DNA. In this approach, diverse variants of a sequence of interest are first ranked according to their activities in a relevant pooled assay, and this ranking is then...read more

    Mentioned in this Paper

    Amino Acids, Essential
    Antibiotics
    Antibiotics, Aminoglycoside
    Antibiotics, Antitubercular
    DNA
    12
    4
    Paper Details
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