Comprehensive mutational scanning of a kinase in vivo reveals substrate-dependent fitness landscapes

doi:10.1101/004317

Comprehensive mutational scanning of a kinase in vivo reveals substrate-dependent fitness landscapes

bioRxiv

Apr 18, 2014

Alexandre MelnikovTarjei S Mikkelsen

PMID: 990004317

DOI: 10.1101/004317

Abstract

Deep mutational scanning has emerged as a promising tool for mapping sequence-activity relationships in proteins, RNA and DNA. In this approach, diverse variants of a sequence of interest are first ranked according to their activities in a relevant pooled assay, and this ranking is then...read more

Mentioned in this Paper

Amino Acids, Essential

Assay

In Vivo

Antibiotics

Antibiotics, Aminoglycoside

Antibiotics, Antitubercular

Phosphotransferases

Protein Engineering

Entamoeba coli

RNA

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