Comprehensive neurotoxicity assessment

Environmental Health Perspectives
B M Kulig

Abstract

Significant progress has been made in recent years in terms of both the conceptualization of neurotoxicity assessment strategies as well as in the development of behavioral techniques for evaluating neurotoxic exposures. A tiered approach, for example, has been advocated as an assessment strategy in which testing would proceed in a stepwise fashion from general screening using simple behavioral methods and neuropathology (tier 1) to the characterization of effects (tier 2) using more specific testing techniques. With respect to tier-1 testing, behavioral observational methods have been standardized for screening purposes, and these technically simple techniques, together with automated methods for motor activity assessment, are being increasingly incorporated into chemical and drug safety evaluations for regulatory purposes. With respect to tier-2 testing, more technically sophisticated techniques and behavioral paradigms are available for characterizing the behavioral effects of chemical exposures on motor, sensory, and cognitive processes. Paradigms involving learned and unlearned behavior, for example, have been described for quantifying a variety of clinical signs of motor impairment including paretic gait disorders, tremor...Continue Reading

References

May 1, 1979·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·F B JolicoeurA Barbeau
Mar 29, 1979·The New England Journal of Medicine·H L NeedlemanP Barrett
Jun 1, 1977·Toxicology and Applied Pharmacology·P M Edwards, V H Parker
May 1, 1990·Neurotoxicology and Teratology·H A TilsonW J Rogan
Jul 1, 1990·Physiology & Behavior·A J Parker, K A Clarke
Jul 1, 1990·Behavioral and Neural Biology·P J Bushnell
Jun 1, 1990·Journal of Neuroscience Methods·H WiethölterA Stevens
Aug 1, 1990·Toxicology and Applied Pharmacology·K M CroftonR Janssen
Apr 1, 1989·Journal of Pharmacological Methods·H SteinbergH Tillotson
Feb 1, 1987·Journal of Applied Toxicology : JAT·G T PryorR A Howd
Dec 1, 1986·Journal of Pharmacological Methods·J D JohnsonG E Isom
Sep 15, 1985·Toxicology and Applied Pharmacology·V C MoserR L Balster
Aug 1, 1985·IEEE Transactions on Bio-medical Engineering·M S Lehtinen, P R Gothóni
Nov 1, 1982·Toxicology and Applied Pharmacology·J M GerhartH A Tilson
May 1, 1983·The Journal of the Acoustical Society of America·J S Young, L D Fechter
Apr 1, 1982·Environmental Health Perspectives·W C Stebbins
Jul 1, 1993·Neurotoxicology and Teratology·A F YoussefC Cox
Mar 1, 1957·Journal of the American Pharmaceutical Association·N W DUNHAM, T S MIYA

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Citations

Aug 11, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Richard A BeckerA Michael Kaplan
Sep 30, 2014·Regulatory Toxicology and Pharmacology : RTP·Joseph HanigSerguei Liachenko
May 2, 2015·PloS One·Ingrid Astrid Jiménez BarbosaSieu K Khuu
Jan 29, 2008·Toxicology and Industrial Health·Mohamed KhalilAhmed E Ahmed
Nov 16, 2010·Toxicologic Pathology·Virginia C Moser
Dec 8, 2009·International Journal of Toxicology·J H C M LammersB M Kulig
Apr 1, 1996·Environmental Health Perspectives·B KuligD Peakall
Sep 1, 2019·International Journal of Toxicology·David V GauvinMary-Jeanne Kallman

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