Comprehensive outcomes after lung retransplantation: A single-center review

Clinical Transplantation
Kieran HalloranLianne G Singer

Abstract

Lung retransplantation is an important therapy for a growing population of lung transplant recipients with graft failure, but detailed outcome data are lacking. We conducted a retrospective cohort study of adult lung retransplant in the Toronto Lung Transplant Program from 2001 to 2013 (n = 38). We analyzed the postoperative course, graft function, renal function, microbiology, donor-specific antibodies (DSA), quality of life, and survival compared to a control cohort of primary transplant recipients matched for age and era. Indication for retransplant was chronic lung allograft dysfunction in most retransplant recipients (35/38, 92%). The postoperative course was more complex after retransplant than primary (ventilation time, 8 vs 2 days, P < .01; ICU stay 14 vs 4 days, P < 0.01), and peak lung function was lower (FEV1 2.2L vs 3L, P < .01). Quality of life scores were comparable, as were renal function, microbiology, and donor-specific antibody formation. Median survival was 1988 days after primary and 1475 days after retransplant (P = .39). Lung retransplantation is associated with a more complex postoperative course and lower peak lung function, but the long-term medical profile is similar to primary transplant. Lung retrans...Continue Reading

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Citations

Apr 3, 2019·Current Opinion in Organ Transplantation·Stijn E VerledenGeert M Verleden
Jul 24, 2020·European Respiratory Review : an Official Journal of the European Respiratory Society·Sophie C van der MarkMerel E Hellemons
May 16, 2019·Current Opinion in Organ Transplantation·Stijn E VerledenGeert M Verleden
Mar 31, 2021·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Andrew T SageShaf Keshavjee
May 25, 2021·Seminars in Respiratory and Critical Care Medicine·Hanne BeeckmansRobin Vos
Aug 23, 2021·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Lorriana E LeardKathleen J Ramos
Dec 23, 2021·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Ilhan InciKonrad Hoetzenecker

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