Comprehensive Phenotyping of Human Dendritic Cells and Monocytes.

Cytometry. Part a : the Journal of the International Society for Analytical Cytology
Florian Mair, Thomas Liechti

Abstract

Professional antigen-presenting cells (APCs), which include dendritic cells (DCs) and monocytes are essential for inducing and steering adaptive T-cell responses. Recent technological developments in single-cell analysis have significantly advanced our understanding of APC subset heterogeneity. To accurately resolve this functional diversity and to account for tissue-specific adaptation, novel phenotyping markers have been described more recently. While some of these largely overlap with traditionally used markers, more fine-grained phenotyping might be essential during inflammatory settings, where the traditional distinction between monocytes and dendritic cells has become blurred. Within this phenotype report, we provide a concise overview of traditional and recently described markers for the phenotyping of DCs and monocytes in the human system.

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Citations

Oct 25, 2020·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Claudia CarenzaSilvia Della Bella
Oct 9, 2021·Clinical Science·Laura MarongiuFrancesca Granucci

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