Comprehensive Profile of Cardiopulmonary Exercise Testing in Ambulatory Persons with Multiple Sclerosis

Sports Medicine
Rachel E KlarenRobert W Motl

Abstract

The study and application of exercise in multiple sclerosis (MS) often requires cardiopulmonary exercise testing (CPET) to provide a comprehensive assessment of exercise tolerance and responses, including an evaluation of the pulmonary, cardiovascular, and skeletal muscle systems. Research on CPET in persons with MS has considerable limitations, including small sample sizes, often without controls; not reporting outcomes across disability status; and different modalities of exercise testing across studies. Although some key outcome variables of CPET have been studied in persons with MS, additional calculated variables have not been directly studied. The objective of this study was to provide a comprehensive examination of outcome variables from CPET among persons with MS and healthy controls. We included data from 162 persons with MS and 80 healthy controls who underwent CPET on a leg ergometer and satisfied criteria for valid testing for measuring oxygen uptake (VO2), carbon dioxide production (VCO2), ventilation (VE), respiratory exchange ratio, work rate, and heart rate (HR). Calculated variables [i.e. ventilatory anaerobic threshold (VO2/VCO2), VE/VCO2 slope, VO2/power slope, VO2/HR slope, and oxygen uptake efficiency slope...Continue Reading

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Citations

Oct 18, 2016·Scandinavian Journal of Medicine & Science in Sports·E SebastiãoR W Motl
Dec 26, 2017·SAGE Open Medicine·Stine Maren RiksfjordInger-Lise Aamot
Dec 12, 2018·Medicine and Science in Sports and Exercise·Elizabeth A HubbardB O Fernhall
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Apr 2, 2020·Multiple Sclerosis : Clinical and Laboratory Research·Robert W MotlBradley P Sutton
May 12, 2018·Acta Neurologica Scandinavica·E Sebastião, R W Motl
Apr 30, 2021·Acta Neurologica Scandinavica·Corey D FeaselRobert W Motl

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