Comprehensive Proteomic Analysis Reveals Intermediate Stage of Non-Lesional Psoriatic Skin and Points out the Importance of Proteins Outside this Trend

Scientific Reports
Edit SzélGergely Groma

Abstract

To better understand the pathomechanism of psoriasis, a comparative proteomic analysis was performed with non-lesional and lesional skin from psoriasis patients and skin from healthy individuals. Strikingly, 79.9% of the proteins that were differentially expressed in lesional and healthy skin exhibited expression levels in non-lesional skin that were within twofold of the levels observed in healthy and lesional skin, suggesting that non-lesional skin represents an intermediate stage. Proteins outside this trend were categorized into three groups: I. proteins in non-lesional skin exhibiting expression similar to lesional skin, which might be predisposing factors (i.e., CSE1L, GART, MYO18A and UGDH); II. proteins that were differentially expressed in non-lesional and lesional skin but not in healthy and lesional skin, which might be non-lesional characteristic alteration (i.e., CHCHD6, CHMP5, FLOT2, ITGA7, LEMD2, NOP56, PLVAP and RRAS); and III. proteins with contrasting differential expression in non-lesional and lesional skin compared to healthy skin, which might contribute to maintaining the non-lesional state (i.e., ITGA7, ITGA8, PLVAP, PSAPL1, SMARCA5 and XP32). Finally, proteins differentially expressed in lesions may indic...Continue Reading

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Citations

Jan 30, 2021·Scientific Reports·Hyung Jin HahnJong-Yeup Kim
Apr 3, 2021·Journal of Proteomics·Wenjun WangLiangdan Sun
Jul 10, 2021·Free Radical Biology & Medicine·Radrezza SilviaD'Amato Alfonsina
Jul 4, 2021·The Journal of Investigative Dermatology·Evelyn KelemenMárta Széll
Aug 2, 2021·The Journal of Investigative Dermatology·Chiara AngiolilliJorg van Loosdregt
Nov 1, 2021·Journal of the European Academy of Dermatology and Venereology : JEADV·S SchalkaM S Baptista
Nov 2, 2021·Journal of the European Academy of Dermatology and Venereology : JEADV·Z DajnokiA Szegedi

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Methods Mentioned

BETA
biopsies
biopsy
reversed-phase chromatography

Software Mentioned

IPA
Ingenuity Pathway Analysis software ( IPA
RISmed R
limma
Proteome Discoverer
ProteinProspector

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