Comprehensive pulmonary rehabilitation in patients with bronchiolitis obliterans syndrome: A case series

Respiratory Medicine Case Reports
Hee Eun ChoiSe-Heum Park

Abstract

Chronic graft-versus-host disease (GVHD) is a significant complication of allogeneic hematopoietic stem cell transplantation, affecting 30%-70% of transplant recipients. One of the most challenging manifestations of chronic pulmonary GVHD is bronchiolitis obliterans syndrome (BOS), a rare and difficult-to-diagnose disease associated with a high mortality rate. BOS results in progressive circumferential fibrosis and, ultimately, cicatrization of the small terminal airways, manifesting as new fixed airflow obstruction. Although BOS patients are typically treated with immunosuppressive agents, there is no strong evidence that any specific therapies are effective in improving long-term outcomes. Thus, the mortality rate remains high. Therefore, there is an increasing need for additional therapies, including pulmonary rehabilitation (PR), in patients with BOS. PR is an evidence-based and comprehensive intervention for patients with chronic obstructive lung disease aimed at alleviating respiratory symptoms and optimizing functional capacity. This present case series demonstrates that comprehensive PR may also improve exercise tolerance and dyspnea in patients with BOS.

References

Apr 6, 2006·The European Respiratory Journal·P W Jones, A G N Agusti
Sep 22, 2010·COPD·Cristine E Berry, Robert A Wise
Dec 4, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Brandon K C AuJason W Chien
Feb 4, 2012·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Jerry TranKaren L Wood
Nov 13, 2012·The European Respiratory Journal·Magnus Thorsten JensenGorm B Jensen
Jun 4, 2013·European Respiratory Review : an Official Journal of the European Respiratory Society·Pierre-Régis BurgelDaniel Dusser

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Methods Mentioned

BETA
MDS

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Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

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