Comprehensive radionuclide esophagogastrointestinal transit study: methodology, reference values, and initial clinical experience

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Alexander J AntoniouHarvey A Ziessman

Abstract

A radionuclide methodology and reference values have been developed for a single gastrointestinal transit study including esophageal transit, liquid and solid gastric emptying, and small- and large-bowel transit, using (111)In-diethylenetriaminepentaacetic acid (DTPA) with the standardized (99m)Tc-labeled solid meal. Eighteen healthy subjects and 18 patients were investigated. The esophageal transit study was performed with 3.7 MBq (0.1 mCi) of (111)In-DTPA in 15 mL of water. A liquid-only 30-min gastric-emptying study followed, with ingestion of 3.7 MBq (0.1 mCi) of (111)In-DTPA in 300 mL of water. Then, a simultaneous solid-liquid emptying study was acquired after ingestion of a solid (99m)Tc-sulfur colloid-labeled meal and 7.4 MBq (0.2 mCi) of (111)In-DTPA in 120 mL of water. Images were acquired intermittently for 4 h. Additional (111)In images were acquired at 5 and 6 h to measure small-bowel transit, and at 24, 48, and 72 h for large-bowel transit. Reference values were determined for esophageal transit (transit time, percentage emptying at 10 s), liquid-only gastric emptying (emptying half-time), liquid and solid emptying in a dual-phase solid-liquid study (emptying half-time and percentage emptying at 1, 2, 3, and 4 h),...Continue Reading

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Citations

Sep 30, 2016·Current Treatment Options in Gastroenterology·Harvey A Ziessman
Apr 16, 2019·Clinical Nuclear Medicine·Lilja B SolnesHarvey A Ziessman
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Mar 5, 2016·Journal of Nuclear Medicine Technology·Alan H Maurer
Mar 15, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Federica GuidoccioGiuliano Mariani

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