Comprehensive study of dynamic curing effect on tablet coating structure

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Claire GendreJean Manuel Péan

Abstract

The dissolution method is still widely used to determine curing end-points to ensure long-term stability of film coatings. Nevertheless, the process of curing has not yet been fully investigated. For the first time, joint techniques were used to elucidate the mechanisms of dynamic curing over time from ethylcellulose (Aquacoat)-based coated tablets. X-ray micro-computed tomography (XμCT), Near Infrared (NIR), and Raman spectroscopies as well as X-ray microdiffraction were employed as non-destructive techniques to perform direct measurements on tablets. All techniques indicated that after a dynamic curing period of 4h, reproducible drug release can be achieved and no changes in the microstructure of the coating were any longer detected. XμCT analysis highlighted the reduced internal porosity, while both NIR and Raman measurements showed that spectral information remained unaltered after further curing. X-ray microdiffraction revealed densification of the coating layer with a decrease in the overall coating thickness of about 10 μm as a result of curing. In addition, coating heterogeneity attributed to cetyl alcohol was observed from microscopic images and Raman analysis. This observation was confirmed by X-ray microdiffraction t...Continue Reading

References

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Citations

Jun 26, 2013·International Journal of Pharmaceutics·Claire GendreJean Manuel Péan
Oct 16, 2013·International Journal of Pharmaceutics·J Siepmann, F Siepmann
Jan 8, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Krisztina NikowitzGéza Regdon
Oct 18, 2015·International Journal of Pharmaceutics·Zsombor CsobánIstván Antal
Aug 27, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Klemen KorasaFranc Vrečer
Sep 12, 2020·Pharmaceutics·Ki-Soo SeoHyo-Kyung Han

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