Comprehensive study on structure-activity relationships of rifamycins: discussion of molecular and crystal structure and spectroscopic and thermochemical properties of rifamycin O

Journal of Medicinal Chemistry
A BacchiP Ferrari

Abstract

The mechanism of action of rifamycins against bacterial DNA-dependent RNA polymerase has been explained on the basis of the spatial arrangement of four oxygens which can form hydrogen bonds with the enzyme. Structural descriptors are derived from X-ray diffraction crystal structures of 25 active and nonactive rifamycins. Principal component analysis is used to find the combination of structural parameters which better discriminate between active and nonactive rifamycins. Two possible mechanisms of molecular rearrangement are described which can convert nonactive into active conformations. The energy involved for conformational rearrangements is studied by molecular modeling techniques. Methyl C34 is found to play a key role for determining the geometry of the pharmacophore. Rifamycin O, reported to be active, is obtained by oxidation of rifamycin B and is studied by X-ray single-crystal diffractometry, by solution IR and NMR spectroscopy, and by thermal analysis. Surprisingly the oxidation process is totally stereospecific, and an explanation is given based on solution spectroscopic evidence. The conformation found in the solid state is typical of nonactive compounds, and molecular mechanics calculations show that a molecular r...Continue Reading

References

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Citations

Sep 1, 2014·European Journal of Medicinal Chemistry·Giovanna PoceMariangela Biava
Mar 20, 2010·Tuberculosis·Paul A AristoffH D Showalter
Jul 19, 2011·Journal of Mass Spectrometry : JMS·Krystian Pyta, Piotr Przybylski
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Aug 1, 2012·Biopharmaceutics & Drug Disposition·José Eduardo GonçalvesSílvia Storpirtis
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Apr 6, 2000·The Journal of Organic Chemistry·R Chênevert, Y S Rose
Apr 29, 2020·EcoSal Plus·Hamed Mosaei, Nikolay Zenkin

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