Comprehensive Surgical Staging in Stage 1 Clear Cell and Endometrioid Ovarian Carcinomas: Is it Necessary?

International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
Radha R PadhyR J Kurman

Abstract

The objective of this article was to evaluate the presence of occult metastasis after comprehensive surgical staging of clear cell ovarian carcinoma (CCC) and endometrioid ovarian carcinoma (EMCA) that appeared to be confined to the ovary at time of surgery. Between 1998 to 2016, 85 patients with CCC and EMCA were identified who were comprehensively staged and felt to be stage 1 intraoperatively. Of the 85 patients who underwent surgical staging, 4 (4.7%) had omental and dense pelvic side-wall tumor adhesions. On final pathology, 67 (79%) patients were diagnosed as stage 1A of which 29 (43%) patients were upstaged to 1C1 due to intraoperative rupture. The remaining 18 (21%) patients were staged as 1C2/1C3. The 1- and 5-yr disease-free survival for pathology stage 1A tumors was 94% and 76%, respectively, and for 1C2/1C3 tumors was 100% and 75%, respectively. Among patients who received adjuvant chemotherapy, the 5-yr disease-free survival was near equal for pathology stage 1A and 1C2/1C3 groups (73% vs. 74%), with a lower 5-yr disease-free survival for CCC compared with EMCA (72% vs. 78%). There were 16 (19%) recurrences with 12 being pathology stage 1A. Of these 12 patients, 9 (75%) had CCC of which 2 received adjuvant chemothe...Continue Reading

References

Mar 5, 2009·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·P J TimmersJ B Trimbos
Feb 16, 2010·The American Journal of Surgical Pathology·Robert J Kurman, Ie-Ming Shih
Apr 12, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul J HoskinsKenneth D Swenerton
Jul 18, 2012·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Mika MizunoFumitaka Kikkawa
Jun 6, 2013·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Haider MahdiAdnan R Munkarah
Jul 11, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Kayo SuzukiAikou Okamoto
Sep 5, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Aalok KumarPaul J Hoskins
Oct 25, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Aikou OkamotoAmit Oza
Sep 26, 2015·Gynecologic Oncology·Catherine A ShuCarol A Aghajanian
Oct 29, 2015·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Jennifer J MuellerMario M Leitao
Mar 26, 2016·The American Journal of Pathology·Robert J Kurman, Ie-Ming Shih

❮ Previous
Next ❯

Citations

Nov 28, 2018·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Randi WoodbeckMartin Köbel
Jul 9, 2021·Obstetrics and Gynecology·Shayan DiounJason D Wright

❮ Previous
Next ❯

Methods Mentioned

BETA
hysterectomy
dissection

Related Concepts

Related Feeds

Adenocarcinoma, Clear Cell

Clear Cell Adenocarcinoma is a tumor that arises in the female genital tract and is characterized by cells that appear clear under the microscope. Discover the latest research here.

Related Papers

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Kayo SuzukiAikou Okamoto
International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Mika MizunoF Kikkawa
International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Toshio TakadaKen Takizawa
Annals of Oncology : Official Journal of the European Society for Medical Oncology
D Lorusso, S Pignata
© 2022 Meta ULC. All rights reserved