Abstract
The objective of this article was to evaluate the presence of occult metastasis after comprehensive surgical staging of clear cell ovarian carcinoma (CCC) and endometrioid ovarian carcinoma (EMCA) that appeared to be confined to the ovary at time of surgery. Between 1998 to 2016, 85 patients with CCC and EMCA were identified who were comprehensively staged and felt to be stage 1 intraoperatively. Of the 85 patients who underwent surgical staging, 4 (4.7%) had omental and dense pelvic side-wall tumor adhesions. On final pathology, 67 (79%) patients were diagnosed as stage 1A of which 29 (43%) patients were upstaged to 1C1 due to intraoperative rupture. The remaining 18 (21%) patients were staged as 1C2/1C3. The 1- and 5-yr disease-free survival for pathology stage 1A tumors was 94% and 76%, respectively, and for 1C2/1C3 tumors was 100% and 75%, respectively. Among patients who received adjuvant chemotherapy, the 5-yr disease-free survival was near equal for pathology stage 1A and 1C2/1C3 groups (73% vs. 74%), with a lower 5-yr disease-free survival for CCC compared with EMCA (72% vs. 78%). There were 16 (19%) recurrences with 12 being pathology stage 1A. Of these 12 patients, 9 (75%) had CCC of which 2 received adjuvant chemothe...Continue Reading
References
Mar 18, 2008·Cancer·Dawn J StoreyHani Gabra
Apr 9, 2008·Gynecologic Oncology·John K ChanDaniel S Kapp
Mar 5, 2009·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·P J TimmersJ B Trimbos
Oct 14, 2009·Gynecologic Oncology·Martin KöbelKenneth D Swenerton
Feb 16, 2010·The American Journal of Surgical Pathology·Robert J Kurman, Ie-Ming Shih
Oct 1, 2011·Gynecologic Oncology·Makiko HigashiFumitaka Kikkawa
Apr 12, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul J HoskinsKenneth D Swenerton
Jul 18, 2012·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Mika MizunoFumitaka Kikkawa
Jun 6, 2013·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Haider MahdiAdnan R Munkarah
Jul 11, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Kayo SuzukiAikou Okamoto
Sep 5, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Aalok KumarPaul J Hoskins
Oct 25, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Aikou OkamotoAmit Oza
Sep 26, 2015·Gynecologic Oncology·Catherine A ShuCarol A Aghajanian
Oct 29, 2015·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Jennifer J MuellerMario M Leitao
Mar 26, 2016·The American Journal of Pathology·Robert J Kurman, Ie-Ming Shih
Dec 3, 2016·Gynecologic Oncology·Dimitrios NasioudisKevin Holcomb
Citations
Nov 28, 2018·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Randi WoodbeckMartin Köbel
Apr 15, 2021·Gynecologic Oncology·Renée E W M van de VorstCornelis G Gerestein
Jul 9, 2021·Obstetrics and Gynecology·Shayan DiounJason D Wright