Comprehensive tumor profiling-guided therapy in rare or refractory solid cancer: A feasibility study in daily clinical practice

Bulletin du cancer
Tony IbrahimMarwan Ghosn

Abstract

Tumor profiling has been shown to benefit patients with rare or refractory metastatic cancer, but several limitations hamper its use in daily clinical practice. We aim to assess the added benefit of a comprehensive tumor profiling, including factors predictive of response to targeted and cytotoxic therapy, in the treatment of refractory or rare solid tumors outside of a formal clinical trial. Patients were included between 2013 and 2017. Multiplatform comprehensive tumor profiling (CTP) was performed on FFPE specimens. Tumor response was evaluated by imaging using the RECIST criteria version 1.1. The PFS ratio was defined as PFS under CTP-guided therapy (PFS2)/PFS under previous standard therapy (PFS1). A clinical benefit was identified if the PFS ratio exceeded the 1.3 threshold value. In total, 184 patients were enrolled among whom 104 were evaluable for the PFS ratio. Objective response rates (ORR) were equal to 25% (CI95: 16.6-33.4%) and 36.5% (CI95: 27.2-45.8%) on the last therapy before CTP and on the CTP-guided therapy respectively (P-value=0.058 on paired proportion comparison test). The proportion of patients achieving a PFS2/PFS1 ratio≥1.3 was equal to 50%. The median PFS1 was statistically lower than PFS2 (120 days c...Continue Reading

References

May 20, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E RahkoA Jukkola
Apr 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Olivier L ChinotDominique Figarella-Branger
May 30, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael S BraunMatthew T Seymour
Nov 26, 2008·Cancer Biology & Therapy·Iwona K KolasaJolanta Kupryjanczyk
Jan 2, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Matthew H KulkeMark S Redston
Mar 25, 2009·Breast Cancer Research : BCR·Swati A KulkarniDouglas T Ross
May 14, 2009·Anti-cancer Drugs·Karoline HorisbergerUNKNOWN MARGIT (Mannheimer Arbeitsgruppe für Gastrointestinale Tumoren)
Oct 6, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel D Von HoffRobert Penny
Dec 30, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael F PressDennis J Slamon
Mar 4, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Chung-Yu ChenPan-Chyr Yang
Apr 1, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Ruiz-Soto RodrigoLe Cesne Axel
Sep 6, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Weiyi GongJingcheng Dong
Oct 5, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel D Von HoffManuel Hidalgo
Dec 24, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Goli SamimiWarner K Huh
Feb 7, 2012·Cell·Janet E DanceyThomas J Hudson
Feb 7, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Hai-Long ZhangXi-Wu Zhou
Jun 12, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Song GaoJian Gao
Sep 12, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Apostolia-Maria TsimberidouRazelle Kurzrock
Sep 28, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Filip JankuRazelle Kurzrock
Aug 3, 2013·Biomarkers in Medicine·Lars Petter Jordheim, Charles Dumontet
Jul 16, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Jingwei YuLin Shen
Sep 5, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xin Fu LiuLong Hua Chen
Jul 17, 2015·JAMA Oncology·Himisha BeltranMark A Rubin
Aug 26, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Maria SchwaederleRazelle Kurzrock
Feb 14, 2016·Molecular Cancer Therapeutics·Maria SchwaederleRazelle Kurzrock
Jun 2, 2016·Expert Opinion on Drug Metabolism & Toxicology·Nicholas Li-Xun SynSoo-Chin Lee
Oct 30, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K A Olaussen, S Postel-Vinay
Jan 29, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·O TrédanUNKNOWN ProfiLER investigators

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