Comprehensive two-dimensional gas chromatography-mass spectrometry: a review

Mass Spectrometry Reviews
Luigi MondelloGiovanni Dugo

Abstract

Although comprehensive two-dimensional gas chromatography (GC x GC) has been on the scene for more than 15 years, it is still generally considered a relatively novel technique and is yet far from being fully established. The revolutionary aspect of GC x GC, with respect to classical multidimensional chromatography, is that the entire sample is subjected to two distinct analytical separations. The resulting enhanced separating capacity makes this approach a prime choice when GC analysts are challenged with highly complex mixtures. The combination of a third mass spectrometric dimension to a GC x GC system generates the most powerful analytical tool today for volatile and semi-volatile analytes. The present review is focused on the rather brief, but not scant, history of comprehensive two-dimensional GC-MS: the first experiments were carried out at the end of the 1990s and, since then, the methodology has been increasingly studied and applied. Almost all GC x GC-MS applications have been carried out by using either a time-of-flight or quadrupole mass analyzer; significant experiments relative to a variety of research fields, as well as advantages and disadvantages of the MS systems employed, are discussed. The principles, practic...Continue Reading

References

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Citations

Jun 11, 2011·Analytical and Bioanalytical Chemistry·Zhong-Da ZengPhilip J Marriott
Jan 18, 2012·Analytical and Bioanalytical Chemistry·Martin F AlmstetterKatja Dettmer
Mar 4, 2009·Molecular Biotechnology·Arnis KuksisHeikki Kallio
Jul 20, 2010·Annual Review of Analytical Chemistry·Stephen J Blanksby, Todd W Mitchell
Aug 7, 2014·Journal of the American Society for Mass Spectrometry·Matthew BrantleyTouradj Solouki
Jun 3, 2011·The Journal of Biological Chemistry·Zhentian LeiLloyd W Sumner
Feb 3, 2015·Drug Metabolism Reviews·Bo Wen, Mingshe Zhu
Jul 4, 2012·Journal of Chromatography. a·Peter Quinto Tranchida, Luigi Mondello
Jun 26, 2012·Journal of Chromatography. a·Karisa M PierceRobert E Synovec
Dec 27, 2011·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Miloslav SandaBohumír Koutek
Aug 23, 2011·Journal of Chromatography. a·Stephen E ReichenbachQingping Tao
Oct 2, 2014·Mass Spectrometry Reviews·Peter Q TranchidaLuigi Mondello
May 7, 2010·Journal of Chromatography. a·Kevin M Van GeemGuy B Marin
Feb 9, 2010·Journal of Chromatography. a·Peter Quinto TranchidaLuigi Mondello
Aug 25, 2009·Journal of Chromatography. a·Miguel HerreroJose Bernal
Jul 15, 2009·Journal of Chromatography. a·Peter Quinto TranchidaLuigi Mondello

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