Comprehensive two-dimensional gas chromatography-mass spectrometry: a review

Mass Spectrometry Reviews
Luigi MondelloGiovanni Dugo


Although comprehensive two-dimensional gas chromatography (GC x GC) has been on the scene for more than 15 years, it is still generally considered a relatively novel technique and is yet far from being fully established. The revolutionary aspect of GC x GC, with respect to classical multidimensional chromatography, is that the entire sample is subjected to two distinct analytical separations. The resulting enhanced separating capacity makes this approach a prime choice when GC analysts are challenged with highly complex mixtures. The combination of a third mass spectrometric dimension to a GC x GC system generates the most powerful analytical tool today for volatile and semi-volatile analytes. The present review is focused on the rather brief, but not scant, history of comprehensive two-dimensional GC-MS: the first experiments were carried out at the end of the 1990s and, since then, the methodology has been increasingly studied and applied. Almost all GC x GC-MS applications have been carried out by using either a time-of-flight or quadrupole mass analyzer; significant experiments relative to a variety of research fields, as well as advantages and disadvantages of the MS systems employed, are discussed. The principles, practic...Continue Reading


Jun 24, 2000·Journal of Chromatography. a·M M van DeurseC A Cramers
Oct 31, 2002·Analytical Chemistry·Robert Shellie, Philip J Marriott
Jul 25, 2003·Journal of Chromatography. a·Jens DallügeUdo A Th Brinkman
Dec 3, 2003·Journal of Chromatography. a·Minna KallioMarja-Liisa Riekkola
Sep 1, 2004·Journal of Separation Science·Robert ShellieLuigi Mondello
Sep 1, 2004·Journal of Separation Science·Russell W LaclairJohn V Seeley
Dec 15, 2004·Journal of Chromatography. a·Shin Miin SongPaul Wynne
Apr 20, 2005·Analytical and Bioanalytical Chemistry·Renuka MayadunnePhilip J Marriott
Apr 30, 2005·Analytical Chemistry·Frank Cheng-Yu WangLarry A Green

❮ Previous
Next ❯


Jun 11, 2011·Analytical and Bioanalytical Chemistry·Zhong-Da ZengPhilip J Marriott
Jan 18, 2012·Analytical and Bioanalytical Chemistry·Martin F AlmstetterKatja Dettmer
Mar 4, 2009·Molecular Biotechnology·Arnis KuksisHeikki Kallio
Jul 20, 2010·Annual Review of Analytical Chemistry·Stephen J Blanksby, Todd W Mitchell
Aug 7, 2014·Journal of the American Society for Mass Spectrometry·Matthew BrantleyTouradj Solouki
Jun 3, 2011·The Journal of Biological Chemistry·Zhentian LeiLloyd W Sumner
Feb 3, 2015·Drug Metabolism Reviews·Bo Wen, Mingshe Zhu
Jul 4, 2012·Journal of Chromatography. a·Peter Quinto Tranchida, Luigi Mondello
Jun 26, 2012·Journal of Chromatography. a·Karisa M PierceRobert E Synovec
Dec 27, 2011·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Miloslav SandaBohumír Koutek
Aug 23, 2011·Journal of Chromatography. a·Stephen E ReichenbachQingping Tao
Oct 2, 2014·Mass Spectrometry Reviews·Peter Q TranchidaLuigi Mondello
May 7, 2010·Journal of Chromatography. a·Kevin M Van GeemGuy B Marin
Feb 9, 2010·Journal of Chromatography. a·Peter Quinto TranchidaLuigi Mondello
Aug 25, 2009·Journal of Chromatography. a·Miguel HerreroJose Bernal
Jul 15, 2009·Journal of Chromatography. a·Peter Quinto TranchidaLuigi Mondello

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.