Comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry (GC x GC-TOFMS) for drug screening and confirmation

Forensic Science International : Synergy
Shin Miin SongP M Wynne

Abstract

Comprehensive two-dimensional gas chromatography (GC x GC) is applied to analysis of drug standard mixtures containing 78 drugs of interest in forensic samples. For this study, underivatised drugs were employed. While several of the drugs were not detected at the low concentrations employed in the samples, most could be satisfactorily assigned their first and second dimension retentions in the GC x GC retention plane. For this study, time-of-flight mass spectrometry (TOFMS) detection was used. The enhanced separation possible in GC x GC is demonstrated, and typical linearity and apparatus precision are shown for tramadol, diazepam, olanzapine and desipramine using selected qualifier ions. Mass spectral library search quality for the detection of drugs in a selection of authentic forensic cases, along with retention position in the 2D retention plane, is used to support positive identification of the presence of the drugs. The analysis of 'difficult' drugs paracetamol and phenytoin is shown to produce anomalous chromatographic peak shape in the 2D plane, whereas most drugs gave acceptable peak shapes. The GC x GC technique was applied to screening drugs in forensic samples, with either flame ionisation (FID) or TOFMS detection, ...Continue Reading

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Citations

Jul 20, 2011·Analytical and Bioanalytical Chemistry·Blagoj MitrevskiPhilip J Marriott
Dec 15, 2004·Journal of Chromatography. a·Shin Miin SongPaul Wynne
Aug 12, 2006·Omics : a Journal of Integrative Biology·Jason M HoganEugene Kolker
Jun 21, 2007·Journal of Analytical Toxicology·Michael L SmithMarilyn A Huestis
Sep 4, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Chao YuanSihe Wang
May 3, 2007·Biomedical Chromatography : BMC·Leah N Williamson, Michael G Bartlett
Nov 12, 2014·Bioanalysis·Yong Foo WongPhilip J Marriott
Jan 22, 2008·Journal of Chromatography. a·M AdahchourU A Th Brinkman
Feb 2, 2008·Mass Spectrometry Reviews·Luigi MondelloGiovanni Dugo
Aug 22, 2017·Monatshefte für chemie·Hubert BylińskiJacek Namieśnik
Jan 27, 2005·Journal of Mass Spectrometry : JMS

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