Comprehensive two-dimensional gas chromatography in stop-flow mode

Journal of Separation Science
James Harynuk, Tadeusz Górecki

Abstract

The theory and proof of concept of a new mode of operation for comprehensive two-dimensional gas chromatography (GC x GC) is presented. In current GC x GC interface designs, the modulation period defines the separation time allowed in the second dimension. In the stop-flow GC x GC mode, flow in the primary column is periodically stopped for brief periods of time. Consequently, the modulation period for the primary column and the amount of time available for second dimension separation become independent variables. This allows the separations in both the primary and secondary dimensions of the GC x GC system to be carried out under more optimised conditions, allowing extended periods of time for second dimension separations without sacrificing the separation in the primary dimension. This new technique has the potential to offer increased separation power and overall resolution as it is further developed.

References

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Dec 3, 2003·Journal of Chromatography. a·James Harynuk, Tadeusz Górecki

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Citations

May 20, 2008·Analytical and Bioanalytical Chemistry·Minna KallioTuulia Hyötyläinen
Jun 1, 2011·Analytical and Bioanalytical Chemistry·Matthew EdwardsTadeusz Górecki
Mar 20, 2012·Journal of Chromatography. a·Ahmed MostafaTadeusz Górecki
Feb 9, 2010·Journal of Chromatography. a·Ján KrupcíkPat Sandra
Mar 21, 2008·Journal of Chromatography. a·Frank Cheng-Yu Wang
Jan 22, 2008·Journal of Chromatography. a·M AdahchourU A Th Brinkman
Nov 26, 2015·Journal of Chromatography. a·Chris E FreyeRobert E Synovec
Sep 23, 2008·Journal of Separation Science·John V SeeleyJames D McCurry
Sep 18, 2008·Journal of Separation Science·Nathan OldridgeTadeusz Górecki
Oct 26, 2005·Journal of Chromatography. a·James Harynuk, Tadeusz Górecki
Nov 30, 2013·Sensors·Tomasz DymerskiJacek Namieśnik
Dec 1, 2017·Critical Reviews in Analytical Chemistry·Tomasz Dymerski
Jan 11, 2020·Critical Reviews in Analytical Chemistry·John Mommers, Sjoerd van der Wal
Jan 26, 2007·Analytical Chemistry·John V SeeleyJames D McCurry

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