Compressed sensing in quantitative determination of GAG concentration in cartilage by microscopic MRI

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Nian WangYang Xia

Abstract

To evaluate the potentials of compressed sensing (CS) in MRI quantification of glycosaminoglycan (GAG) concentration in articular cartilage at microscopic resolution. T1 -weighted 2D experiments of cartilage were fully sampled in k-space with five inversion times at 17.6 μm resolution. These fully sampled k-space data were re-processed, by undersampling at various 1D and 2D CS undersampling factors (UFs). The undersampled data were reconstructed individually into 2D images using nonlinear reconstruction, which were used to calculate 2D maps of T1 and GAG concentration. The values of T1 and GAG in cartilage were evaluated at different UFs (up to 16, which used 6.25% of the data). K-space sampling pattern and zonal variations were also investigated. Using 2D variable density sampling pattern, the T1 images at UFs up to eight preserved major visual information and produced negligible artifacts. The GAG concentration remained accurate for different sub-tissue zones at various UFs. The variation of the mean GAG concentration through the whole tissue depth was 1.20%, compared to the fully sampled results. The maximum variation was 2.24% in the deep zone of cartilage. Using 1D variable density sampling pattern, the quantitative T1 map...Continue Reading

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Citations

Oct 9, 2018·Journal of Magnetic Resonance Imaging : JMRI·Marcelo V W ZibettiRavinder R Regatte
Jan 24, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Nian WangG Allan Johnson
Jul 3, 2019·European Radiology·Bénédicte Marie Anne DelattreMaria Isabel Vargas
Jan 22, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Nian WangG Allan Johnson
Apr 22, 2019·Brain Structure & Function·Nian WangG Allan Johnson
Sep 19, 2018·Brain Structure & Function·Nian WangG Allan Johnson
Dec 14, 2018·Physics in Medicine and Biology·Nian WangG Allan Johnson
May 13, 2021·Journal of Neural Engineering·Aliesha GarrettXiling Shen

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