Compressed sensing of remotely detected MRI velocimetry in microfluidics

Journal of Magnetic Resonance
Jeffrey PaulsenA Pines

Abstract

NMR and MRI can yield detailed chemical and dynamic information about flow at microscopic resolutions, but suffer from low signal to noise relative to alternative techniques for flow measurements. In porous media and microfluidic devices, this sensitivity problem is further exacerbated by magnetic susceptibility broadening and low coil filling factor. Fortunately, remote detection can mitigate these issues by physically separating signal detection from the other steps of the experiment. The technique requires, however, that any measured interactions be encoded in indirectly sampled dimensions, leading to experiments of high dimensionality and correspondingly long acquisition times. We have applied compressed sensing, a reconstruction technique used in MRI, to dramatically reduce these experiment times by 8-64x through partial sampling (sub-sampling) of k-space, allowing for the collection of images with significantly higher resolutions in reasonable amounts of time. Here, we demonstrate this reconstruction technique to remotely detected flow measurements in a serpentine mixing chip and in a microfluidic channel harboring a constriction. We find that compressed sensing allows for significantly higher resolution images to be coll...Continue Reading

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Citations

Feb 26, 2013·Lab on a Chip·Vladimir V ZhivonitkoIgor V Koptyug
Mar 12, 2011·Annual Review of Analytical Chemistry·Raluca M Fratila, Aldrik H Velders
Dec 3, 2014·Journal of Magnetic Resonance·Nicholas W Halpern-MannersVikram S Bajaj
Dec 30, 2011·Journal of Magnetic Resonance·Guillaume MadelinRavinder R Regatte
Mar 6, 2012·Journal of Magnetic Resonance·Thomas Z TeisseyreAlexander Pines
Sep 20, 2011·Journal of Magnetic Resonance·Jeffrey L PaulsenYi-Qiao Song
Mar 25, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·David J MichalakAlexander Pines
Oct 21, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Marion I MenzelLuca Marinelli
Dec 14, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Wen LiXin Yu
Sep 15, 2015·Journal of Magnetic Resonance·Khieu-Van NguyenLuisa Ciobanu
Feb 14, 2015·Journal of Magnetic Resonance·S H HanJ L Paulsen
Feb 24, 2015·Journal of Magnetic Resonance·E O FridjonssonM L Johns
May 4, 2011·Angewandte Chemie·Eva Paciok, Bernhard Blümich
Mar 16, 2011·The Journal of Physical Chemistry. a·Nicholas W Halpern-MannersAlexander Pines

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