PMID: 8945902Nov 1, 1996Paper

Compressibility of perfused passive myocardium

The American Journal of Physiology
F C YinR M Judd

Abstract

In most theoretical analyses of the heart, the tissue has been assumed to be incompressible. Because the myocardium is extensively perfused with distensible vessels, increasing the stiffness of the surrounding tissue, as with contraction or passive stretching, should decrease the volume of fluid in these vessels. Using a digital subtraction angiographic method, we quantified the amount of vascular volume extruded from six passive, perfused canine interventricular septa during cyclic biaxial loading from 300 to 900 g force. At pressures from 0 to 120 mmHg the amount of fluid extruded during a loading cycle varied from 2 to 4 ml/100 g tissue at 0 and 120 mmHg, respectively. This volume change increased with perfusion pressure and was significantly greater at 120 than at 0, 30, or 60 mmHg. The amount of fluid extruded was on the same order as that estimated during active contraction or with a 60-mmHg change in perfusion pressure. The finding that perfused myocardium is compressible implies that results from existing analyses of the heart assuming incompressibility are not realistic. Such analyses must account for compressibility with, e.g., mixture theory or other similar approaches.

Citations

Nov 16, 2001·American Journal of Physiology. Heart and Circulatory Physiology·A J CornelissenF C Yin
Jun 27, 2013·International Journal for Numerical Methods in Biomedical Engineering·J WongE Kuhl
Feb 19, 2014·Computer Methods in Biomechanics and Biomedical Engineering·F Barış Can CansızMichael Kaliske
Dec 14, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Allen ChengNeil B Ingels
Nov 29, 2017·International Journal for Numerical Methods in Biomedical Engineering·Joventino Oliveira CamposBernardo Martins Rocha
May 28, 2019·Biomechanics and Modeling in Mechanobiology·Brian D HongTimothy W Secomb
Jul 14, 2018·Journal of Biomechanical Engineering·Eoin McEvoyPatrick McGarry
Dec 29, 2010·Biomechanics and Modeling in Mechanobiology·M K RauschE Kuhl
Nov 30, 2006·Computer Methods in Biomechanics and Biomedical Engineering·F DorriP P Lunkenheimer
Jun 1, 2012·International Journal for Numerical Methods in Biomedical Engineering·Simone RossiAlfio Quarteroni
Jan 1, 2017·International Journal for Numerical Methods in Biomedical Engineering·Gabriel BalabanSamuel Wall
Feb 23, 2021·The International Journal of Cardiovascular Imaging·Jonathan Carl Luis RodriguesDavid H MacIver
Jan 1, 2021·Medical Image Analysis·Luigi E PerottiDaniel B Ennis

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