Compression of Cerebellar Functional Gradients in Schizophrenia.

Schizophrenia Bulletin
Debo DongDezhong Yao

Abstract

Our understanding of cerebellar involvement in brain disorders has evolved from motor processing to high-level cognitive and affective processing. Recent neuroscience progress has highlighted hierarchy as a fundamental principle for the brain organization. Despite substantial research on cerebellar dysfunction in schizophrenia, there is a need to establish a neurobiological framework to better understand the co-occurrence and interaction of low- and high-level functional abnormalities of cerebellum in schizophrenia. To help to establish such a framework, we investigated the abnormalities in the distribution of sensorimotor-supramodal hierarchical processing topography in the cerebellum and cerebellar-cerebral circuits in schizophrenia using a novel gradient-based resting-state functional connectivity (FC) analysis (96 patients with schizophrenia vs 120 healthy controls). We found schizophrenia patients showed a compression of the principal motor-to-supramodal gradient. Specifically, there were increased gradient values in sensorimotor regions and decreased gradient values in supramodal regions, resulting in a shorter distance (compression) between the sensorimotor and supramodal poles of this gradient. This pattern was observed...Continue Reading

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Citations

Nov 10, 2020·International Journal of Neural Systems·Sisi JiangCheng Luo
Aug 19, 2020·Neuroscience and Biobehavioral Reviews·Ana P PinheiroSonja A Kotz
Jan 18, 2021·NeuroImage·Xinyu LiangGaolang Gong
Apr 4, 2021·International Journal of Molecular Sciences·Michela LupoMaria Leggio
May 7, 2021·Schizophrenia Bulletin·Sheeba Arnold AnteraperSusan Whitfield-Gabrieli
Jun 9, 2021·Psychological Medicine·Debo DongCheng Luo
Jul 13, 2021·NeuroImage·Olivia K HarrisonRobert L Barry
Aug 15, 2021·NeuroImage·Jiahe ZhangSusan Whitfield-Gabrieli

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