Compression of pellets coated with various aqueous polymer dispersions

International Journal of Pharmaceutics
A DashevskyR Bodmeier

Abstract

Pellets coated with a new aqueous polyvinyl acetate dispersion, Kollicoat SR 30 D, could be compressed into tablets without rupture of the coating providing unchanged release profiles. In contrast, the compression of pellets coated with the ethylcellulose dispersion, Aquacoat ECD 30, resulted in rupture of the coating and an increase in drug release. Plasticizer-free Kollicoat SR coatings were too brittle and ruptured during compression. The addition of only 10% w/w triethyl citrate as plasticizer improved the flexibility of the films significantly and allowed compaction of the pellets. The drug release was almost independent of the compression force and the pellet content of the tablets. The inclusion of various tabletting excipients slightly affected the drug release, primarily because of a different disintegration rate of the tablets. The core size of the starting pellets had no influence on the drug release. Pellets coated with the enteric polymer dispersion Kollicoat 30 D MAE 30 DP [poly(methacrylic acid, ethyl acrylate) 1:1] lost their enteric properties after compression because of the brittle properties of this enteric polymer. Coating of pellets with a mixture of Kollicoat MAE 30 DP and Kollicoat EMM 30 D [poly(ethyl a...Continue Reading

References

Jan 1, 1988·European Journal of Clinical Pharmacology·A SandbergJ Sjögren
Jun 23, 2004·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·A DashevskyR Bodmeier

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Citations

Mar 13, 2009·Pharmaceutical Research·Simon EnsslinKarsten Mäder
Oct 1, 2013·International Journal of Pharmaceutics·K KolterR Bodmeier
Jan 10, 2008·AAPS PharmSciTech·Linda A Felton
Feb 15, 2007·Pakistan Journal of Biological Sciences : PJBS·Muhammad Khan SarfrazSabeeh Mohsin
Sep 1, 2008·Indian Journal of Pharmaceutical Sciences·V S N Murthy Dwibhashyam, J Vijaya Ratna
Sep 4, 2015·Pharmaceutical Development and Technology·Zhen YangDongkai Wang
May 27, 2009·Drug Development and Industrial Pharmacy·Wieslaw Sawicki, Jaroslaw Mazgalski
Aug 30, 2011·Drug Development and Industrial Pharmacy·Sandra U KuceraJames W McGinity
May 5, 2009·Drug Development and Industrial Pharmacy·Stuart L CantorLarry L Augsburger
Dec 15, 2004·Drug Development and Industrial Pharmacy·Alessandro GainottiFerdinando Giordano
Jan 24, 2013·Expert Opinion on Drug Delivery·Linda A Felton, Stuart C Porter
Jan 25, 2008·Drug Development and Industrial Pharmacy·Dinesh Mahadeorao MorkhadeSiddheshwar B Joshi
Jun 11, 2015·Journal of Pharmaceutical Sciences·Frederick Osei-Yeboah, Changquan Calvin Sun
May 23, 2012·Journal of Pharmaceutical Sciences·Pan LiuYongqing Fan
Jan 13, 2016·International Journal of Pharmaceutics·Eva Julia LaukampJoerg Breitkreutz
Jan 25, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Soravoot Rujivipat, Roland Bodmeier
Feb 22, 2011·International Journal of Pharmaceutics·Dima Ghanam, Peter Kleinebudde
Jan 19, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·J C O VillanovaR L Oréfice
Aug 24, 2010·International Journal of Pharmaceutics·Sandra U Schilling, James W McGinity
Apr 25, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Simon EnsslinKarsten Mäder
Feb 6, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Ana Gómez-CarracedoJose Luis Gómez-Amoza
Nov 21, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·F SiepmannR Bodmeier
Dec 25, 2012·Pharmaceutical Development and Technology·Chien NguyenJames W Ayres
Oct 19, 2016·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Xueying Tan, Jingbo Hu
Jan 22, 2010·Pharmaceutical Development and Technology·Rok DreuStanko Srčič
Jan 12, 2017·AAPS PharmSciTech·Rodrigo Gomes de AlencarRicardo Neves Marreto
Jul 4, 2009·The EMBO Journal·Yuehua WeiX F Steven Zheng
Sep 25, 2010·Omics : a Journal of Integrative Biology·Luciano GaldieriAles Vancura
Sep 1, 2013·Therapeutic Innovation & Regulatory Science·Xin PanChuanbin Wu
Aug 23, 2008·Pharmaceutical Development and Technology·Diego GallardoPeter Kleinebudde
Jan 21, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Isamu SaekiToshiyuki Niwa

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