Compression of the facial nerve caused increased nitric oxide synthase activity in the facial motor nucleus

Neuroscience
P T WongK H Yeoh

Abstract

Nitric oxide synthase activities in the facial motor nucleus were studied in rats after unilateral compression of the facial nerve. Using a radiometric assay which measured the total soluble nitric oxide synthase activities in the facial motor nucleus and the surrounding tissues, it was found that nitric oxide synthase activities were markedly increased during facial paralysis that resulted from compression of the facial nerve. The subsequent decrease in nitric oxide synthase activities between postoperative days 20 and 40 coincided with the recovery of facial functions. In contrast, staining with NADPH-diaphorase histochemistry revealed that the diaphorase activities in the facial motor neurons were markedly increased between days 20-40 when the total activities as measured biochemically were in decline. However, staining of the vascular endothelium was increased on postoperative day 7 when the total activity was high. It is suggested that the increase in total nitric oxide synthase activities immediately after facial nerve compression may be predominantly endothelial. Since the increase in neuronal NADPH-diaphorase reactivity coincided with the recovery of facial functions, increased neuronal nitric oxide synthase may be a co...Continue Reading

References

May 1, 1975·Acta Oto-laryngologica·E Yamamoto, U Fisch
Jan 1, 1992·Neuroscience·S R Vincent, H Kimura
Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·B T HopeS R Vincent
Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·T M DawsonS H Snyder
May 1, 1990·The Annals of Otology, Rhinology, and Laryngology·C G JacksonD S Poe
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R G KnowlesS Moncada
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D S Bredt, S H Snyder
Mar 1, 1989·Metabolic Brain Disease·G W KreutzbergW J Streit
May 1, 1983·Acta Oto-laryngologica·U Fisch, H Felix
Mar 1, 1994·Neuroscience·N J DunU Förstermann
Jan 1, 1993·Neuroreport·J RegidorI Divac

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Citations

Dec 24, 2005·Anatomy and Embryology·J CalkaM Lakomy
Mar 9, 2004·Brain Research. Brain Research Reviews·Linda B Moran, Manuel B Graeber
Feb 6, 2007·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Makoto ItoShigeo Okoyama
Nov 15, 1996·Neuroscience Letters·R Mariotti, M Bentivoglio
Apr 12, 2001·The European Journal of Neuroscience·R MariottiM Bentivoglio
Mar 28, 1998·The European Journal of Neuroscience·T González-HernándezM Rodríguez
Jun 22, 2002·Annals of the New York Academy of Sciences·Seng-Kee LeongZhi Zhang
Oct 14, 2005·Journal of the Peripheral Nervous System : JPNS·Leonard BerenholzGad M Gilad
Jan 12, 2000·Free Radical Research·S K Leong

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