Compression Ratio Ion Mobility Programming (CRIMP) Accumulation and Compression of Billions of Ions for Ion Mobility-Mass Spectrometry Using Traveling Waves in Structures for Lossless Ion Manipulations (SLIM)

Analytical Chemistry
Liulin DengRichard D Smith

Abstract

We report on the implementation of a traveling wave (TW) based compression ratio ion mobility programming (CRIMP) approach within structures for lossless ion manipulations (SLIM) that enables both greatly enlarged trapped ion charge capacities and also efficient ion population compression for use in ion mobility (IM) separations. Ion accumulation is conducted in a SLIM serpentine ultralong path with extended routing (SUPER) region after which CRIMP compression allows the large ion populations to be "squeezed". The SLIM SUPER IM module has two regions, one operating with conventional traveling waves (i.e., traveling trap; TT region) and the second having an intermittently pausing or "stuttering" TW (i.e., stuttering trap; ST region). When a stationary voltage profile was used in the ST region, ions are blocked at the TT-ST interface and accumulated in the TT region and then can be released by resuming a conventional TW in the ST region. The population can also be compressed using CRIMP by the repetitive merging of ions distributed over multiple TW bins in the TT region into a single TW bin in the ST region. Ion accumulation followed by CRIMP compression provides the basis for the use of larger ion populations for IM separations....Continue Reading

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Citations

Dec 14, 2017·Journal of the American Society for Mass Spectrometry·Aneesh PrabhakaranRichard D Smith
Apr 9, 2019·Analytical and Bioanalytical Chemistry·Ansgar T KirkStefan Zimmermann
Sep 8, 2019·Journal of the American Society for Mass Spectrometry·James N Dodds, Erin S Baker
Mar 6, 2021·Journal of the American Society for Mass Spectrometry·Adam L HollerbachYehia M Ibrahim
Apr 3, 2021·Analytical Chemistry·Brian H ClowersJohn Daniel DeBord
Aug 25, 2020·Trends in Analytical Chemistry : TRAC·Sandilya V B GarimellaRichard D Smith

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