Compression stockings attenuate the expression of proteins associated with vascular damage in human varicose veins.

Journal of Vascular Surgery. Venous and Lymphatic Disorders
Guillermo MoñuxAntonio López-Farré

Abstract

The objective of this study was to analyze whether compression stocking therapy in the human varicose vein wall may change the levels of biomarkers associated with vein insufficiency. Dilated collateral varicose vein samples were obtained from patients showing chronic venous disease (class 2 of the Clinical, Etiology, Anatomy, and Pathophysiology classification). Before elective surgery, 12 patients underwent compression stocking therapy (for 1 month) and 9 patients did not (control group). Expression levels of biomarkers associated with endothelial functionality (nitric oxide synthase 3), inflammation (interleukin-6, interleukin-10), oxidative stress (Gp91phox subunit of NADPH oxidase), and coagulation (factor Xa) were determined. P-selectin, an inflammatory and thrombosis-related biomarker, was also measured. Compression stockings increased the content of nitric oxide synthase 3 (control, 16.48 [16.04-17.40] AU; compression, 83.71 [67.70-91.85] AU; P < .001) in the varicose vein wall that was accompanied by reduction of both interleukin-6 levels (control, 38.72 [33.48-48.52] pg/μg protein; compression, 14.49 [11.05-17.41] pg/μg protein; P = .001) and the expression of Gp91phox subunit of NADPH oxidase (control, 63.24 [53.79-7...Continue Reading

References

Apr 1, 1990·The British Journal of Surgery·P C Jeffery, A N Nicolaides
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D D ReesS Moncada
Feb 26, 1999·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·G D MotykieD Mokhtee
Nov 5, 1999·Current Problems in Dermatology·H Partsch
Dec 12, 2001·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·S J HollingsworthS G Barker
Oct 23, 2002·Circulation·Joshua A Beckman
Mar 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Claudia NiemandGerhard Müller-Newen
Sep 19, 2003·Pathophysiology of Haemostasis and Thrombosis·P Poredos
Sep 18, 2004·Stroke; a Journal of Cerebral Circulation·Matthias Endres, Ulrich Laufs
Jan 18, 2006·Thrombosis and Haemostasis·John E RectenwaldThomas W Wakefield
May 1, 1949·The Journal of Clinical Investigation·J R StantonR W Wilkins
Aug 4, 2006·The New England Journal of Medicine·John J BerganBo Eklof
Jan 10, 2012·Journal of Vascular Surgery·Javier ModregoGuillermo Moñux
Aug 24, 2012·VASA. Zeitschrift für Gefässkrankheiten·Uwe Müller-BühlGunter Laux
Dec 27, 2012·JAMA : the Journal of the American Medical Association·Allen Hamdan
Sep 10, 2013·Thrombosis Research·Constantine N AntonopoulosChristos D Liapis
Mar 5, 2014·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Chung Sim Lim, Alun H Davies
Jul 22, 2014·British Journal of Clinical Pharmacology·Antonio J López-FarréGuillermo Moñux
Jun 24, 2015·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·P PoredosM K Jezovnik
Jan 10, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Robert M RestainoJaume Padilla
Jul 10, 2017·Annals of Vascular Surgery·Ricardo Castro-FerreiraArmando Mansilha
Jul 25, 2017·British Journal of Clinical Pharmacology·Guillermo MoñuxAntonio López-Farré
Jun 8, 2018·International Journal of Molecular Sciences·Armando Mansilha, Joel Sousa
Jul 19, 2018·São Paulo Medical Journal = Revista Paulista De Medicina·Ricardo de Ávila OliveiraJosé Carlos da Costa Baptista-Silva
Oct 26, 2018·The Korean Journal of Internal Medicine·Young Jin Youn, Juyong Lee

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