PMID: 9165392Jun 1, 1997Paper

Compressive behavior of articular cartilage is not completely explained by proteoglycan osmotic pressure

Journal of Biomechanics
P S Khalsa, S R Eisenberg

Abstract

It has been hypothesized that applied mechanical or osmotic loads which decrease cartilage volume by 5% or more are sufficient to relieve all collagen tensile forces, and that further changes in the applied load are completely supported by changes in proteoglycan osmotic pressure. In this view, cartilage should behave mechanically like a concentrated solution of proteoglycans. We tested this hypothesis by measuring the equilibrium axial and radial stresses in bovine articular cartilage during uniaxial confined compression. If the hypothesis is correct, the observed changes in the radial and axial stresses in confined compression should be equal for compression greater than 5%. However, the observed change in axial stress was always substantially greater than the change in radial stress over the range of strains (5-26%) and saline concentrations (0.05-0.15 M) tested. This indicates that the mechanical behavior of cartilage in confined compression cannot solely be explained by changes in proteoglycan osmotic pressure even for strains as large as 26%. A linear isotropic model was found to describe the observed equilibrium behavior adequately. In addition, the inferred shear modulus was found to be independent of saline concentrati...Continue Reading

References

Feb 1, 1979·Acta Orthopaedica Scandinavica·T Havdrup
May 1, 1991·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·K A AthanasiouV C Mow
Jan 1, 1990·Experimental Pathology·R G Johnson, A R Poole
Jan 1, 1985·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·S R Eisenberg, A J Grodzinsky
Jan 1, 1984·Journal of Biomechanics·V C MowW M Lai
Feb 1, 1980·Journal of Biomechanical Engineering·V C MowC G Armstrong
Jun 1, 1994·Calcified Tissue International·A M GarcíaM L Gray
Nov 1, 1993·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·W ZhuD R Eyre

❮ Previous
Next ❯

Citations

May 20, 1999·Journal of Magnetic Resonance Imaging : JMRI·J H KaufmanJ S Leigh
Mar 17, 2004·Biochemical and Biophysical Research Communications·Xuhui LiuZong-Ping Luo
Feb 22, 2003·Journal of Biomechanics·Christopher C-B WangGerard A Ateshian
Oct 19, 2000·Journal of Biomechanical Engineering·P BursaćD Stamenović
Jul 28, 2007·Journal of Biomechanical Engineering·Sean S KohlesLawrence J Bonassar
Jul 9, 1999·Journal of Biomechanical Engineering·J SoulhatA Shirazi-Adl
Aug 10, 2011·Journal of Biomechanical Engineering·Nicolas V JaumardBeth A Winkelstein
Aug 31, 2001·Biochemical and Biophysical Research Communications·K J GoochL E Freed
Feb 22, 2014·Journal of the Mechanical Behavior of Biomedical Materials·Hyunchul AhnWoong-Ryeol Yu
Jun 12, 2014·Tissue Engineering. Part a·Regina F MacBarbKyriacos A Athanasiou
Mar 5, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Eleftherios A MakrisKyriacos A Athanasiou
Jan 6, 2009·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Roman M NatoliKyriacos A Athanasiou
Jul 16, 2003·Biochemical and Biophysical Research Communications·Xuhui LiuZong-Ping Luo
Aug 17, 2011·Osteoarthritis and Cartilage·R MahmoodianS Siegler
Oct 29, 2014·Proceedings of the National Academy of Sciences of the United States of America·Eleftherios A MakrisKyriacos A Athanasiou
Dec 3, 2014·Journal of the Mechanical Behavior of Biomedical Materials·Chen-Yuan Chung, Joseph M Mansour
Dec 17, 2016·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Paolo BaudiCarla Palumbo
Nov 3, 2017·Soft Matter·Jarosław Paturej, Torsten Kreer
Nov 21, 2015·The Open Orthopaedics Journal·M E PedersenN M Jomha
Apr 4, 2014·Reports on Progress in Physics·Donald E IngberDimitrije Stamenovic
Nov 12, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Eva G Baylon, Marc E Levenston
May 6, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Donald E Ingber
Jun 17, 2003·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·J S JurvelinE B Hunziker
Jan 12, 2007·Journal of Applied Biomechanics·Zeike A Taylor, Karol Miller
Nov 28, 2020·Scientific Reports·Stefano Perni, Polina Prokopovich
Nov 20, 2020·Journal of Biomechanical Engineering·Brandon K ZimmermanGerard A Ateshian
Jan 21, 2021·Journal of the Royal Society, Interface·Dillon M BrownC Ross Ethier
Mar 15, 2005·Biomacromolecules·Ferenc HorkayPeter J Basser
Sep 9, 2009·Journal of Theoretical Biology·C A Chung, Chih-Yuan Chen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.