Compromised Humoral Functional Evolution Tracks with SARS-CoV-2 Mortality.

Cell
Tomer ZoharGalit Alter

Abstract

The urgent need for an effective SARS-CoV-2 vaccine has forced development to progress in the absence of well-defined correlates of immunity. While neutralization has been linked to protection against other pathogens, whether neutralization alone will be sufficient to drive protection against SARS-CoV-2 in the broader population remains unclear. Therefore, to fully define protective humoral immunity, we dissected the early evolution of the humoral response in 193 hospitalized individuals ranging from moderate to severe. Although robust IgM and IgA responses evolved in both survivors and non-survivors with severe disease, non-survivors showed attenuated IgG responses, accompanied by compromised Fcɣ receptor binding and Fc effector activity, pointing to deficient humoral development rather than disease-enhancing humoral immunity. In contrast, individuals with moderate disease exhibited delayed responses that ultimately matured. These data highlight distinct humoral trajectories associated with resolution of SARS-CoV-2 infection and the need for early functional humoral immunity.

References

Apr 15, 2004·Immunology Letters·Marielle A Otten, Marjolein van Egmond
Oct 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Aravind SubramanianJill P Mesirov
Dec 8, 2007·Nature Reviews. Immunology·Falk Nimmerjahn, Jeffrey V Ravetch
Jun 9, 2009·Current Opinion in Immunology·Laura Haynes, Alexander C Maue
Jan 6, 2010·Current Opinion in HIV and AIDS·Georgia D Tomaras, Barton F Haynes
Mar 9, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Peter BergqvistMats Bemark
May 14, 2010·Clinical and Vaccine Immunology : CVI·Stanley A Plotkin
Jan 5, 2011·Journal of Immunological Methods·Margaret E AckermanGalit Alter
Oct 2, 2012·Journal of Immunological Methods·Eric P BrownMargaret E Ackerman
Nov 5, 2014·Frontiers in Immunology·Gestur VidarssonTheo Rispens
Jun 24, 2015·Clinical and Experimental Immunology·L S K Walker, M von Herrath
Jan 9, 2016·Parasitology·Katherine R Dobbs, Arlene E Dent
Feb 6, 2016·Human Brain Mapping·Anderson M WinklerThomas E Nichols
Sep 27, 2016·Cell·Lenette L LuGalit Alter
Apr 1, 2017·Current Opinion in Immunology·William D Green, Melinda A Beck
Oct 25, 2017·Nature Reviews. Immunology·Lenette L LuGalit Alter
Apr 2, 2018·Journal of Immunological Methods·Matthew J WorleyAmy W Chung
Jan 10, 2019·Bioinformatics·Helge HassClemens Kreutz
May 28, 2019·Journal of Immunological Methods·Christina B KarstenGalit Alter
May 31, 2019·Frontiers in Immunology·Jeffrey Y KawaharaGalit Alter
Nov 20, 2019·Nature Methods·Ilya KorsunskySoumya Raychaudhuri
Apr 7, 2020·Nature Reviews. Immunology·Natalie Vaninov
Apr 23, 2020·JAMA : the Journal of the American Medical Association·Safiya RichardsonTheodoros P Zanos
May 1, 2020·Nature Medicine·Quan-Xin LongAi-Long Huang
May 14, 2020·Nature Medicine·Fatima AmanatFlorian Krammer
May 22, 2020·Science·Jingyou YuDan H Barouch
May 22, 2020·Science·Abishek ChandrashekarDan H Barouch
Jun 10, 2020·Nature Reviews. Immunology·Tomer Zohar, Galit Alter
Jun 20, 2020·Nature·Davide F RobbianiMichel C Nussenzweig
Jul 9, 2020·Nature·Elizabeth J WilliamsonBen Goldacre
Jul 17, 2020·Science Immunology·Leticia Kuri-CervantesMichael R Betts
Aug 14, 2020·Immunity·Caroline AtyeoGalit Alter
Sep 3, 2020·Cell·Naoki KanekoUNKNOWN Massachusetts Consortium on Pathogen Readiness Specimen Working Group

❮ Previous
Next ❯

Citations

Jan 27, 2021·Cell·Alessandro Sette, Shane Crotty
Dec 5, 2020·Vaccines·Claudio CostantiniLuigina Romani
Feb 12, 2021·International Immunology·Masayuki Miyasaka
Mar 24, 2021·Expert Opinion on Therapeutic Targets·Simone I Richardson, Penny L Moore
Apr 4, 2021·International Journal of Molecular Sciences·Linhua TianLili Wang
Apr 13, 2021·Brain, Behavior, & Immunity Health·Francisco J Barrantes
May 7, 2021·Nature Medicine·Carolina LucasAkiko Iwasaki
May 13, 2021·Nature Communications·Stefania DispinseriGabriella Scarlatti
May 18, 2021·Cell Reports Medicine·Wen Shi LeeStephen J Kent
Jun 6, 2021·Clinical and Experimental Medicine·Elliot H Akama-Garren, Jonathan X Li
Jun 1, 2021·Cell Reports Medicine·Andrea R ShiakolasIvelin S Georgiev
Jun 16, 2021·Cell Discovery·Jingsong ZhangLuonan Chen
Jul 1, 2021·Oxford Open Immunology·D Oliver ScourfieldStephanie E A Burnell
Jul 2, 2021·The Journal of Clinical Investigation·Yijia LiJonathan Z Li
Jun 2, 2021·Molecules and Cells·Eunjin Lee, Ji Eun Oh
Jul 16, 2021·Cell Host & Microbe·Kanta Subbarao
Jul 29, 2021·Science Translational Medicine·Neeltje van DoremalenVincent J Munster
Aug 6, 2021·Cell·Carly G K ZieglerJose Ordovas-Montanes
Sep 7, 2021·Molecular Systems Biology·Zhixin Cyrillus TanAaron S Meyer

❮ Previous
Next ❯

Methods Mentioned

BETA
glycosylation
flow cytometry
transfection
Assay

Software Mentioned

R package ‘ immunogenomics / LISI ’
ForeCyt
R stats
R
R package ‘ umap ’
python
UMAP
R package ‘ fgsea
Gene Set Enrichment Analysis ( GSEA )

Related Concepts

Related Feeds

Cell eTOC

Cell is a scientific journal publishing research across a broad range of disciplines within the life sciences field. Discover the latest research from Cell here.

Related Papers

The Journal of Immunology : Official Journal of the American Association of Immunologists
Amanda GriffinStephen J McSorley
Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
V V OberemokA V Kubyshkin
© 2021 Meta ULC. All rights reserved